Communications Medicine (Dec 2022)
Performance assessment and economic analysis of a human Liver-Chip for predictive toxicology
- Lorna Ewart,
- Athanasia Apostolou,
- Skyler A. Briggs,
- Christopher V. Carman,
- Jake T. Chaff,
- Anthony R. Heng,
- Sushma Jadalannagari,
- Jeshina Janardhanan,
- Kyung-Jin Jang,
- Sannidhi R. Joshipura,
- Mahika M. Kadam,
- Marianne Kanellias,
- Ville J. Kujala,
- Gauri Kulkarni,
- Christopher Y. Le,
- Carolina Lucchesi,
- Dimitris V. Manatakis,
- Kairav K. Maniar,
- Meaghan E. Quinn,
- Joseph S. Ravan,
- Ann Catherine Rizos,
- John F. K. Sauld,
- Josiah D. Sliz,
- William Tien-Street,
- Dennis Ramos Trinidad,
- James Velez,
- Max Wendell,
- Onyi Irrechukwu,
- Prathap Kumar Mahalingaiah,
- Donald E. Ingber,
- Jack W. Scannell,
- Daniel Levner
Affiliations
- Lorna Ewart
- Emulate Inc.
- Athanasia Apostolou
- Emulate Inc.
- Skyler A. Briggs
- Emulate Inc.
- Christopher V. Carman
- Emulate Inc.
- Jake T. Chaff
- Emulate Inc.
- Anthony R. Heng
- Emulate Inc.
- Sushma Jadalannagari
- Emulate Inc.
- Jeshina Janardhanan
- Emulate Inc.
- Kyung-Jin Jang
- Emulate Inc.
- Sannidhi R. Joshipura
- Emulate Inc.
- Mahika M. Kadam
- Emulate Inc.
- Marianne Kanellias
- Emulate Inc.
- Ville J. Kujala
- Emulate Inc.
- Gauri Kulkarni
- Emulate Inc.
- Christopher Y. Le
- Emulate Inc.
- Carolina Lucchesi
- Emulate Inc.
- Dimitris V. Manatakis
- Emulate Inc.
- Kairav K. Maniar
- Emulate Inc.
- Meaghan E. Quinn
- Emulate Inc.
- Joseph S. Ravan
- Emulate Inc.
- Ann Catherine Rizos
- Emulate Inc.
- John F. K. Sauld
- Emulate Inc.
- Josiah D. Sliz
- Emulate Inc.
- William Tien-Street
- Emulate Inc.
- Dennis Ramos Trinidad
- Emulate Inc.
- James Velez
- Emulate Inc.
- Max Wendell
- Emulate Inc.
- Onyi Irrechukwu
- Janssen Pharmaceuticals, Spring House
- Prathap Kumar Mahalingaiah
- Investigative Toxicology and Pathology, Abbvie
- Donald E. Ingber
- Wyss Institute for Biologically Inspired Engineering, Harvard University
- Jack W. Scannell
- JW Scannell Analytics LTD
- Daniel Levner
- Emulate Inc.
- DOI
- https://doi.org/10.1038/s43856-022-00209-1
- Journal volume & issue
-
Vol. 2,
no. 1
pp. 1 – 16
Abstract
Ewart et al. assess the performance of a human Liver-Chip for predictive toxicology. They also perform an economic analysis to demonstrate its potential financial value for the pharmaceutical industry.
