POST-SURGERY CHANGES IN THE RATES OF ACID-BASE BALANCE AND BLOOD GAS CONTENT IN SURGICAL TREATMENT OF ACQUIRED CARDIAC DEFECTS UNDER CONDITIONS OF NORMAL AND HYPOTHERMIC CARDIOPULMONARY BYPASS

Abstract

The purpose of this study is to assess changes in the rates of acid-base balance in adult cardiac surgery patients with acquired cardiac defects who were operated using hypo- and normothermic cardiopulmonary bypass. Materials and Methods: 140 patients who had surgical treatment of acquired cardiac defects with the use of cardiopulmonary bypass were randomly divided into two similar groups with the use of hypothermic and normothermic cardiopulmonary(31-32˚С and > 36˚С). The rates of acid-base balance were evaluated during peri-operation and post-surgery stages as well as morbidity and mortality during the hospital stage. Results. The patients who had surgery with the use of hypothermic cardiopulmonary bypass, had the level of РаO2 statistically lower one day after surgery compared to the patients who had surgery with normothermic cardiopulmonary bypass. When analyzing the post surgery period with the use of hypothermic cardiopulmonary bypass the duration of artificial pulmonary ventilation was significantly lower compared to the group who had normothermic cardiopulmonary bypass. However it made no impact on duration of stay in the wards for post-surgery follow-up, general duration of hospital stay, frequency of complications and hospital mortality. Conclusion. The results of study demonstrated no statistically significant differences in the rate of acid-base balance in patients who had surgery with normothermic and hypothermic cardiopulmonary bypass. Moreover the changes in acid-base balance in both groups during surgery and post-surgery periods did not go beyond the normal values which indicates the adequate protection of the host from surgery aggression factors.

Keywords

• cardiopulmonary bypass
• hypothermia
• acquired cardiac defects
• acid-base balance