Nature Communications (Oct 2018)
Bi-directional cell-pericellular matrix interactions direct stem cell fate
- Silvia A. Ferreira,
- Meghna S. Motwani,
- Peter A. Faull,
- Alexis J. Seymour,
- Tracy T. L. Yu,
- Marjan Enayati,
- Dheraj K. Taheem,
- Christoph Salzlechner,
- Tabasom Haghighi,
- Ewa M. Kania,
- Oommen P. Oommen,
- Tarek Ahmed,
- Sandra Loaiza,
- Katarzyna Parzych,
- Francesco Dazzi,
- Oommen P. Varghese,
- Frederic Festy,
- Agamemnon E. Grigoriadis,
- Holger W. Auner,
- Ambrosius P. Snijders,
- Laurent Bozec,
- Eileen Gentleman
Affiliations
- Silvia A. Ferreira
- Centre for Craniofacial and Regenerative Biology, King’s College London
- Meghna S. Motwani
- Centre for Craniofacial and Regenerative Biology, King’s College London
- Peter A. Faull
- Protein Analysis and Proteomics Platform, The Francis Crick Institute
- Alexis J. Seymour
- Centre for Craniofacial and Regenerative Biology, King’s College London
- Tracy T. L. Yu
- Centre for Craniofacial and Regenerative Biology, King’s College London
- Marjan Enayati
- Centre for Craniofacial and Regenerative Biology, King’s College London
- Dheraj K. Taheem
- Centre for Craniofacial and Regenerative Biology, King’s College London
- Christoph Salzlechner
- Centre for Craniofacial and Regenerative Biology, King’s College London
- Tabasom Haghighi
- Centre for Craniofacial and Regenerative Biology, King’s College London
- Ewa M. Kania
- Centre for Craniofacial and Regenerative Biology, King’s College London
- Oommen P. Oommen
- Bioengineering and Nanomedicine Lab, Faculty of Biomedical Sciences and Engineering, Tampere University of Technology and BioMediTech Institute
- Tarek Ahmed
- Biomaterials and Tissue Engineering, Eastman Dental Institute, University College London
- Sandra Loaiza
- Cancer Cell Protein Metabolism Group, Department of Medicine, Imperial College London
- Katarzyna Parzych
- Cancer Cell Protein Metabolism Group, Department of Medicine, Imperial College London
- Francesco Dazzi
- Department of Haemato-Oncology, Rayne Institute, King’s College London
- Oommen P. Varghese
- Department of Chemistry, Ångström Laboratory, Science for Life Laboratory, Uppsala University
- Frederic Festy
- Tissue Engineering and Biophotonics, King’s College London
- Agamemnon E. Grigoriadis
- Centre for Craniofacial and Regenerative Biology, King’s College London
- Holger W. Auner
- Cancer Cell Protein Metabolism Group, Department of Medicine, Imperial College London
- Ambrosius P. Snijders
- Protein Analysis and Proteomics Platform, The Francis Crick Institute
- Laurent Bozec
- Biomaterials and Tissue Engineering, Eastman Dental Institute, University College London
- Eileen Gentleman
- Centre for Craniofacial and Regenerative Biology, King’s College London
- DOI
- https://doi.org/10.1038/s41467-018-06183-4
- Journal volume & issue
-
Vol. 9,
no. 1
pp. 1 – 12
Abstract
3D hydrogels have provided information on the physical requirements of stem cell fate, but the contribution of interactions with the pericellular environment are under-explored. Here the authors show that pericellular matrix secreted by human bone marrow stromal cells (hMSC) embedded in a HA-based hydrogel contribute to hMSC fate.
