Nature Communications (Nov 2017)

Novel peptide probes to assess the tensional state of fibronectin fibers in cancer

  • Simon Arnoldini,
  • Alessandra Moscaroli,
  • Mamta Chabria,
  • Manuel Hilbert,
  • Samuel Hertig,
  • Roger Schibli,
  • Martin Béhé,
  • Viola Vogel

DOI
https://doi.org/10.1038/s41467-017-01846-0
Journal volume & issue
Vol. 8, no. 1
pp. 1 – 13

Abstract

Read online

The extracellular matrix is under variable strain, but we lack the tools to detect differences in strain. Here the authors develop a probe based on a bacterial fibronectin-binding peptide that binds to relaxed fibronectin fibrils and detects relaxed matrix in cell culture, tissue slices and in vivo.