309 The role of tumor-draining lymph nodes in the tuning of systemic T cell immunity by CTLA-4 blockade is revealed by local delivery of tremelimumab in early-stage melanoma: data from a Phase-I trial

• Anita Stam,
• Dafni Chondronasiou,
• Karin Jooss,
• Jessica Notohardjo,
• Kim van Pul,
• Sinead Lougheed,
• Petrousjka van den Tol,
• Ronald Vuylsteke,
• Alfons van den Eertwegh,
• Tanja de Gruijl

Affiliations

Anita Stam

Aff1 grid.16872.3a000000040435165XDepartment of Medical OncologyVU University Medical Center, Amsterdam Amsterdam Netherlands

Dafni Chondronasiou

Aff2 grid.16872.3a000000040435165XMedical OncologyVU University Medical Center Amsterdam The Netherlands

Karin Jooss

Aff3 grid.418724.c0000 0004 0408 4133Cell Genesys Inc South San Francisco CA USA

Jessica Notohardjo

1Amsterdam University Medical centers, Vrije Universiteit Amsterdam, Cancer Center Amsterdam, Amsterdam, Netherlands

Kim van Pul

1Amsterdam University Medical centers, Vrije Universiteit Amsterdam, Cancer Center Amsterdam, Amsterdam, Netherlands

Sinead Lougheed

1Amsterdam University Medical centers, Vrije Universiteit Amsterdam, Cancer Center Amsterdam, Amsterdam, Netherlands

Petrousjka van den Tol

1Amsterdam University Medical centers, Vrije Universiteit Amsterdam, Cancer Center Amsterdam, Amsterdam, Netherlands

Ronald Vuylsteke

3Spaarne Gasthuis, Haarlem, Netherlands

Alfons van den Eertwegh

1Amsterdam University Medical centers, Vrije Universiteit Amsterdam, Cancer Center Amsterdam, Amsterdam, Netherlands

Tanja de Gruijl

1Amsterdam University Medical centers, Vrije Universiteit Amsterdam, Cancer Center Amsterdam, Amsterdam, Netherlands