ESCRT-III mediates budding across the inner nuclear membrane and regulates its integrity

Jun Arii; Mizuki Watanabe; Fumio Maeda; Noriko Tokai-Nishizumi; Takahiro Chihara; Masayuki Miura; Yuhei Maruzuru; Naoto Koyanagi; Akihisa Kato; Yasushi Kawaguchi

doi:10.1038/s41467-018-05889-9

Nature Communications (Aug 2018)

ESCRT-III mediates budding across the inner nuclear membrane and regulates its integrity

Jun Arii,
Mizuki Watanabe,
Fumio Maeda,
Noriko Tokai-Nishizumi,
Takahiro Chihara,
Masayuki Miura,
Yuhei Maruzuru,
Naoto Koyanagi,
Akihisa Kato,
Yasushi Kawaguchi

Affiliations

Jun Arii: Division of Molecular Virology, Department of Microbiology and Immunology, The Institute of Medical Science, The University of Tokyo, Minato-ku
Mizuki Watanabe: Division of Molecular Virology, Department of Microbiology and Immunology, The Institute of Medical Science, The University of Tokyo, Minato-ku
Fumio Maeda: Division of Molecular Virology, Department of Microbiology and Immunology, The Institute of Medical Science, The University of Tokyo, Minato-ku
Noriko Tokai-Nishizumi: Microscope Core Laboratory, The Institute of Medical Science, The University of Tokyo, Minato-ku
Takahiro Chihara: Department of Genetics, Graduate School of Pharmaceutical Sciences, The University of Tokyo
Masayuki Miura: Department of Genetics, Graduate School of Pharmaceutical Sciences, The University of Tokyo
Yuhei Maruzuru: Division of Molecular Virology, Department of Microbiology and Immunology, The Institute of Medical Science, The University of Tokyo, Minato-ku
Naoto Koyanagi: Division of Molecular Virology, Department of Microbiology and Immunology, The Institute of Medical Science, The University of Tokyo, Minato-ku
Akihisa Kato: Division of Molecular Virology, Department of Microbiology and Immunology, The Institute of Medical Science, The University of Tokyo, Minato-ku
Yasushi Kawaguchi: Division of Molecular Virology, Department of Microbiology and Immunology, The Institute of Medical Science, The University of Tokyo, Minato-ku

DOI: https://doi.org/10.1038/s41467-018-05889-9
Journal volume & issue: Vol. 9, no. 1
pp. 1 – 15

Abstract

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The endosomal sorting complex required for transport-III (ESCRT-III) has been implicated in the packaging of HIV and HSV-1 viruses in the cytoplasm. Here the authors show that ESCRT-III proteins are required for the transport of HSV-1 nucleocapsids from nucleoplasm to cytosol through the nuclear envelope and confirm that the same mechanism is also used for the nucleocytoplasmic transport of RNP in Drosophila cells.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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