Frontiers in Cardiovascular Medicine (Jan 2025)
Establishment and validation of a nomogram for coronary artery lesions in children with Kawasaki disease
Abstract
BackgroundThe nomogram is a powerful and robust tool in disease risk prediction that summarizes complex variables into a visual model that is interpretable with a quantified risk probability. In the current study, a nomogram was developed to predict the occurrence of coronary artery lesions (CALs) among patients with Kawasaki disease (KD). This is especially valuable in the early identification of the risk of CALs, which will lead to proper diagnosis and treatment to reduce their associated complications.MethodsRetrospective clinical data of 677 children diagnosed with KD who were treated in the Children's Hospital Affiliated with Shandong University were analyzed. All the participants were divided into the CAL group and no CAL group according to their coronary echocardiography results. Least absolute shrinkage and selection operator (LASSO) regression was applied for the identification of the most informative predictors of CAL. Based on this, a nomogram was developed for accurate risk estimation.ResultsThe data were divided into a training set and a validation set. Receiver operating characteristic analysis, calibration curves, and decision curve analysis all supported the high accuracy and clinical utility of this model. LASSO regression highlighted five key predictors: sodium, hemoglobin, platelet count, D-dimer, and cystatin C. A nomogram based on these predictors was established and successfully validated in both datasets. In the training set, the AUC was 0.819 and in the validation set it was 0.844. The C-index of the calibration curve in the training set was 0.820, while in the validation set it was 0.844. In the decision curve analysis, the predictive benefit of the model was greater than zero when the threshold probability was below 95% in the training set and below 92% in the validation set.ConclusionThe predictive factors identified through the LASSO regression approach and the development of the nomogram are important contributions in this respect. This model had a high predictive accuracy and reliability for identifying high-risk children in the very early stage of disease with remarkable precision, laying the foundation for personalized treatment strategies and targeted treatment and providing a strong scientific basis for precise therapeutic intervention.
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