Current evidence for J147 as a potential therapeutic agent in nervous system disease: a narrative review
Fang Qiu,
Yanmei Wang,
Yunbo Du,
Changchun Zeng,
Yuqiang Liu,
Haobo Pan,
Changneng Ke
Affiliations
Fang Qiu
Department of Burn and Plastic Surgery, Shenzhen Longhua District Central Hospital
Yanmei Wang
Department of critical care medicine, Shenzhen Longhua District Central Hospital
Yunbo Du
Department of critical care medicine, Shenzhen Longhua District Central Hospital
Changchun Zeng
Department of Medical Laboratory, Shenzhen Longhua District Central Hospital, Affiliated Central Hospital of Shenzhen Longhua District, Guangdong Medical University
Yuqiang Liu
Department of Anesthesiology, Shenzhen Second People’s Hospital, The First Affiliated Hospital of Shenzhen University
Haobo Pan
Center for Human Tissues and Organs Degeneration, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences
Changneng Ke
Department of Burn and Plastic Surgery, Shenzhen Longhua District Central Hospital
Abstract Curcumin has anti-inflammatory, antioxidant, and anticancer effects and is used to treat diseases such as dermatological diseases, infection, stress, depression, and anxiety. J147, an analogue of curcumin, is designed and synthesized with better stability and bioavailability. Accumulating evidence demonstrates the potential role of J147 in the prevention and treatment of Alzheimer’s disease, diabetic neuropathy, ischemic stroke, depression, anxiety, and fatty liver disease. In this narrative review, we summarized the background and biochemical properties of J147 and discussed the role and mechanism of J147 in different diseases. Overall, the mechanical attributes of J147 connote it as a potential target for the prevention and treatment of neurological diseases.
