Communications Biology (Jan 2021)

Mutational burden and chromosomal aneuploidy synergistically predict survival from radiotherapy in non-small cell lung cancer

  • Qingzhu Jia,
  • Qian Chu,
  • Anmei Zhang,
  • Jing Yu,
  • Fangfang Liu,
  • Kaiyu Qian,
  • Yu Xiao,
  • Xue Wang,
  • Ying Yang,
  • Yi Zhao,
  • Ji He,
  • Guanghui Li,
  • Yisong Y. Wan,
  • Conghua Xie,
  • Bo Zhu

DOI
https://doi.org/10.1038/s42003-021-01657-6
Journal volume & issue
Vol. 4, no. 1
pp. 1 – 7

Abstract

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Here, the authors use whole exome sequencing to determine the effect of tumor mutational burden (TMB) and chromosomal aneuploidy (ANE) on survival outcomes of non-small cell lung cancer patients undergoing radiotherapy. The authors find that a higher TMB and lower ANE were correlated with better survival outcomes and that these factors interact synergistically.