Macrophage accumulation in dorsal root ganglion is associated with neuropathic pain in experimental autoimmune neuritis

Abstract

Neuropathic pain is a common symptom of Guillain–Barré syndrome (GBS). The infiltration of macrophages in the dorsal root ganglion (DRG) contributed to neuropathic pain in nerve injury. The underlying mechanisms of neuropathic pain in patients with GBS remain unknown. Experimental autoimmune neuritis (EAN) is a useful mice model of GBS. Our study aimed to explore whether the infiltration of macrophages in DRG is associated with neuropathic pain of EAN.

Keywords

• macrophages
• dorsal root ganglion
• neuropathic pain
• experimental autoimmune neuritis