Immunogenicity of prime-boost protein subunit vaccine strategies against SARS-CoV-2 in mice and macaques

Hyon-Xhi Tan; Jennifer A. Juno; Wen Shi Lee; Isaac Barber-Axthelm; Hannah G. Kelly; Kathleen M. Wragg; Robyn Esterbauer; Thakshila Amarasena; Francesca L. Mordant; Kanta Subbarao; Stephen J. Kent; Adam K. Wheatley

doi:10.1038/s41467-021-21665-8

Nature Communications (Mar 2021)

Immunogenicity of prime-boost protein subunit vaccine strategies against SARS-CoV-2 in mice and macaques

Hyon-Xhi Tan,
Jennifer A. Juno,
Wen Shi Lee,
Isaac Barber-Axthelm,
Hannah G. Kelly,
Kathleen M. Wragg,
Robyn Esterbauer,
Thakshila Amarasena,
Francesca L. Mordant,
Kanta Subbarao,
Stephen J. Kent,
Adam K. Wheatley

Affiliations

Hyon-Xhi Tan: Department of Microbiology and Immunology, University of Melbourne, at The Peter Doherty Institute for Infection and Immunity
Jennifer A. Juno: Department of Microbiology and Immunology, University of Melbourne, at The Peter Doherty Institute for Infection and Immunity
Wen Shi Lee: Department of Microbiology and Immunology, University of Melbourne, at The Peter Doherty Institute for Infection and Immunity
Isaac Barber-Axthelm: Department of Microbiology and Immunology, University of Melbourne, at The Peter Doherty Institute for Infection and Immunity
Hannah G. Kelly: Department of Microbiology and Immunology, University of Melbourne, at The Peter Doherty Institute for Infection and Immunity
Kathleen M. Wragg: Department of Microbiology and Immunology, University of Melbourne, at The Peter Doherty Institute for Infection and Immunity
Robyn Esterbauer: Department of Microbiology and Immunology, University of Melbourne, at The Peter Doherty Institute for Infection and Immunity
Thakshila Amarasena: Department of Microbiology and Immunology, University of Melbourne, at The Peter Doherty Institute for Infection and Immunity
Francesca L. Mordant: Department of Microbiology and Immunology, University of Melbourne, at The Peter Doherty Institute for Infection and Immunity
Kanta Subbarao: Department of Microbiology and Immunology, University of Melbourne, at The Peter Doherty Institute for Infection and Immunity
Stephen J. Kent: Department of Microbiology and Immunology, University of Melbourne, at The Peter Doherty Institute for Infection and Immunity
Adam K. Wheatley: Department of Microbiology and Immunology, University of Melbourne, at The Peter Doherty Institute for Infection and Immunity

DOI: https://doi.org/10.1038/s41467-021-21665-8
Journal volume & issue: Vol. 12, no. 1
pp. 1 – 10

Abstract

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Current vaccine strategies for SARS-CoV-2 focus on eliciting neutralising antibodies to the spike protein (S), but differences in immunogenicity of full-length S versus receptor binding domain (RBD) only aren’t fully understood. Here, the authors show immunogenicity of different prime-boost strategies with S and/or RBD in mice and macaques.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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