Bioinspired copper single‐atom nanozyme as a superoxide dismutase‐like antioxidant for sepsis treatment
Ji Yang,
Ruofei Zhang,
Hanqing Zhao,
Haifeng Qi,
Jingyun Li,
Jian‐Feng Li,
Xinyao Zhou,
Aiqin Wang,
Kelong Fan,
Xiyun Yan,
Tao Zhang
Affiliations
Ji Yang
Collaborative Innovation Center of Chemistry for Energy Materials (iChEM), Dalian Institute of Chemical Physics Chinese Academy of Sciences Dalian China
Ruofei Zhang
CAS Engineering Laboratory for Nanozyme, Key Laboratory of Protein and Peptide Pharmaceutical, Institute of Biophysics Chinese Academy of Sciences Beijing China
Hanqing Zhao
CAS Engineering Laboratory for Nanozyme, Key Laboratory of Protein and Peptide Pharmaceutical, Institute of Biophysics Chinese Academy of Sciences Beijing China
Haifeng Qi
Collaborative Innovation Center of Chemistry for Energy Materials (iChEM), Dalian Institute of Chemical Physics Chinese Academy of Sciences Dalian China
Jingyun Li
Key Laboratory of Infection and Immunity Institute of Biophysics Chinese Academy of Sciences Beijing China
Jian‐Feng Li
Collaborative Innovation Center of Chemistry for Energy Materials (iChEM) College of Chemistry and Chemical Engineering Xiamen University Xiamen China
Xinyao Zhou
School of Engineering and Applied Science University of Pennsylvania Philadelphia Pennsylvania USA
Aiqin Wang
Collaborative Innovation Center of Chemistry for Energy Materials (iChEM), Dalian Institute of Chemical Physics Chinese Academy of Sciences Dalian China
Kelong Fan
CAS Engineering Laboratory for Nanozyme, Key Laboratory of Protein and Peptide Pharmaceutical, Institute of Biophysics Chinese Academy of Sciences Beijing China
Xiyun Yan
CAS Engineering Laboratory for Nanozyme, Key Laboratory of Protein and Peptide Pharmaceutical, Institute of Biophysics Chinese Academy of Sciences Beijing China
Tao Zhang
Collaborative Innovation Center of Chemistry for Energy Materials (iChEM), Dalian Institute of Chemical Physics Chinese Academy of Sciences Dalian China
Abstract Sepsis is a systemic inflammatory response syndrome with high morbidity and mortality mediated by infection‐caused oxidative stress. Early antioxidant intervention by removing excessively produced reactive oxygen and nitrogen species (RONS) is beneficial to the prevention and treatment of sepsis. However, traditional antioxidants have failed to improve patient outcomes due to insufficient activity and sustainability. Herein, by mimicking the electronic and structural characteristics of natural Cu‐only superoxide dismutase (SOD5), a single‐atom nanozyme (SAzyme) featuring coordinately unsaturated and atomically dispersed Cu‐N4 site was synthesized for effective sepsis treatment. The de novo‐designed Cu‐SAzyme exhibits a superior SOD‐like activity to efficiently eliminate O2•−, which is the source of multiple RONS, thus blocking the free radical chain reaction and subsequent inflammatory response in the early stage of sepsis. Moreover, the Cu‐SAzyme effectively harnessed systemic inflammation and multi‐organ injuries in sepsis animal models. These findings indicate that the developed Cu‐SAzyme possesses great potential as therapeutic nanomedicines for the treatment of sepsis.
