Case Reports in Endocrinology (Jan 2013)

A Case of Hypocalcemia with Severe Vitamin D Deficiency following Treatment for Graves’ Disease with Methimazole

  • Kazuyuki Miyashita,
  • Tetsuyuki Yasuda,
  • Hideaki Kaneto,
  • Akio Kuroda,
  • Tetsuhiro Kitamura,
  • Michio Otsuki,
  • Yasuyuki Okamoto,
  • Noboru Hamada,
  • Munehide Matsuhisa,
  • Iichiro Shimomura

DOI
https://doi.org/10.1155/2013/512671
Journal volume & issue
Vol. 2013

Abstract

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We herein report the case of a 41-year-old Japanese female office worker who developed symptomatic hypocalcemia with severe vitamin D deficiency following treatment for Graves’ disease with methimazole. The patient’s hypocalcemia was mainly caused by vitamin D deficiency due to unbalanced diets and inadequate exposure to sunlight in addition to the resolution of hyperthyroidism. Vitamin D deficiency is increasing worldwide, and it has been more recently shown to relate to the pathogenesis of Graves’ disease. However, vitamin D deficiency as a cause of hypocalcemia has received little attention. Taken together, this case suggests that we should take more care in calcium kinetics and vitamin D status during treatment for Graves’ disease with antithyroid drugs.