Elevation of the Plasma Levels of TNF Receptor 2 in Association with Those of CD25, OX40, and IL-10 and HTLV-1 Proviral Load in Acute Adult T-Cell Leukemia
Megumi Kato,
Naoki Imaizumi,
Reiko Tanaka,
Mariko Mizuguchi,
Masaki Hayashi,
Takashi Miyagi,
Junnosuke Uchihara,
Kazuiku Ohshiro,
Junpei Todoroki,
Kennosuke Karube,
Hiroaki Masuzaki,
Yuetsu Tanaka,
Takuya Fukushima
Affiliations
Megumi Kato
Laboratory of Hematoimmunology, Graduate School of Health Sciences, University of the Ryukyus, Nishihara 903-0215, Japan
Naoki Imaizumi
Laboratory of Molecular Genetics, Graduate School of Health Sciences, University of the Ryukyus, Nishihara 903-0215, Japan
Reiko Tanaka
Laboratory of Hematoimmunology, Graduate School of Health Sciences, University of the Ryukyus, Nishihara 903-0215, Japan
Mariko Mizuguchi
Department of Investigative Medicine, Graduate School of Medicine, University of the Ryukyus, Nishihara 903-0215, Japan
Masaki Hayashi
Department of Hematology, Nakagami Hospital, Okinawa 904-2142, Japan
Takashi Miyagi
Department of Hematology, Heart Life Hospital, Nakagusuku 901-2492, Japan
Junnosuke Uchihara
Department of Hematology, Naha City Hospital, Naha 902-8511, Japan
Kazuiku Ohshiro
Department of Hematology, Okinawa Prefectural Nambu Medical Center and Children’s Medical Center, Naha 901-1193, Japan
Junpei Todoroki
Department of Hematology, Chubu Tokushukai Hospital, Nakagami 901-2305, Japan
Kennosuke Karube
Department of Pathology and Laboratory Medicine, Graduate School of Medicine, Nagoya University, Nagoya 466-8550, Japan
Hiroaki Masuzaki
Division of Endocrinology, Diabetes, and Metabolism, Hematology, Rheumatology, Second Department of Internal Medicine, Graduate School of Medicine, University of the Ryukyus, Nishihara 903-0215, Japan
Yuetsu Tanaka
Laboratory of Hematoimmunology, Graduate School of Health Sciences, University of the Ryukyus, Nishihara 903-0215, Japan
Takuya Fukushima
Laboratory of Hematoimmunology, Graduate School of Health Sciences, University of the Ryukyus, Nishihara 903-0215, Japan
Adult T-cell leukemia/lymphoma (ATL) cells express TNF receptor type-2 (TNFR2) on their surface and shed its soluble form (sTNFR2). We previously reported that sTNFR2 levels were highly elevated in the plasma of patients with acute ATL. To investigate whether its quantitation would be helpful for the diagnosis or prediction of the onset of acute ATL, we examined the plasma levels of sTNFR2 in a large number of specimens obtained from a cohort of ATL patients and asymptomatic human T-cell leukemia virus type 1 (HTLV-1) carriers (ACs) and compared them to those of other candidate ATL biomarkers (sCD25, sOX40, and IL-10) by enzyme-linked immunosorbent assays (ELISA) and HTLV-1 proviral loads. We observed that sTNFR2 levels were significantly elevated in acute ATL patients compared to ACs and patients with other types of ATL (chronic, smoldering, and lymphoma). Importantly, sTNFR2 levels were significantly correlated with those of sCD25, sOX40, and IL-10, as well as proviral loads. Thus, the present study confirmed that an increase in plasma sTNFR2 levels is a biomarker for the diagnosis of acute ATL. Examination of plasma sTNFR2 alone or in combination with other ATL biomarkers may be helpful for the diagnosis of acute ATL.
