Coupling of H3K27me3 recognition with transcriptional repression through the BAH-PHD-CPL2 complex in Arabidopsis

Yi-Zhe Zhang; Jianlong Yuan; Lingrui Zhang; Chunxiang Chen; Yuhua Wang; Guiping Zhang; Li Peng; Si-Si Xie; Jing Jiang; Jian-Kang Zhu; Jiamu Du; Cheng-Guo Duan

doi:10.1038/s41467-020-20089-0

Nature Communications (Dec 2020)

Coupling of H3K27me3 recognition with transcriptional repression through the BAH-PHD-CPL2 complex in Arabidopsis

Yi-Zhe Zhang,
Jianlong Yuan,
Lingrui Zhang,
Chunxiang Chen,
Yuhua Wang,
Guiping Zhang,
Li Peng,
Si-Si Xie,
Jing Jiang,
Jian-Kang Zhu,
Jiamu Du,
Cheng-Guo Duan

Affiliations

Yi-Zhe Zhang: Shanghai Center for Plant Stress Biology and CAS Center for Excellence in Molecular Plant Sciences, Chinese Academy of Sciences
Jianlong Yuan: Shanghai Center for Plant Stress Biology and CAS Center for Excellence in Molecular Plant Sciences, Chinese Academy of Sciences
Lingrui Zhang: Department of Horticulture and Landscape Architecture, Purdue University
Chunxiang Chen: Shanghai Center for Plant Stress Biology and CAS Center for Excellence in Molecular Plant Sciences, Chinese Academy of Sciences
Yuhua Wang: Shanghai Center for Plant Stress Biology and CAS Center for Excellence in Molecular Plant Sciences, Chinese Academy of Sciences
Guiping Zhang: Shanghai Center for Plant Stress Biology and CAS Center for Excellence in Molecular Plant Sciences, Chinese Academy of Sciences
Li Peng: Shanghai Center for Plant Stress Biology and CAS Center for Excellence in Molecular Plant Sciences, Chinese Academy of Sciences
Si-Si Xie: Shanghai Center for Plant Stress Biology and CAS Center for Excellence in Molecular Plant Sciences, Chinese Academy of Sciences
Jing Jiang: State Key Laboratory of Crop Stress Adaptation and Improvement, School of Life Sciences, Henan University
Jian-Kang Zhu: Shanghai Center for Plant Stress Biology and CAS Center for Excellence in Molecular Plant Sciences, Chinese Academy of Sciences
Jiamu Du: Key Laboratory of Molecular Design for Plant Cell Factory of Guangdong Higher Education Institutes, Institute of Plant and Food Science, School of Life Sciences, Southern University of Science and Technology
Cheng-Guo Duan: Shanghai Center for Plant Stress Biology and CAS Center for Excellence in Molecular Plant Sciences, Chinese Academy of Sciences

DOI: https://doi.org/10.1038/s41467-020-20089-0
Journal volume & issue: Vol. 11, no. 1
pp. 1 – 16

Abstract

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Histone 3 Lys 27 trimethylation (H3K27me3) mediates epigenetic silencing of gene expression. Here, Zhang et al. show that in Arabidopsis, the BAH-domain H3K27me3-reader protein AIPP3 forms a complex with PHD proteins and CPL2, a plant-specific Pol II phosphatase, to inhibit Pol II activity by dephosphorylation.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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