Nature Communications (Jan 2018)

Regulatory T cells trigger effector T cell DNA damage and senescence caused by metabolic competition

  • Xia Liu,
  • Wei Mo,
  • Jian Ye,
  • Lingyun Li,
  • Yanping Zhang,
  • Eddy C. Hsueh,
  • Daniel F. Hoft,
  • Guangyong Peng

DOI
https://doi.org/10.1038/s41467-017-02689-5
Journal volume & issue
Vol. 9, no. 1
pp. 1 – 16

Abstract

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Regulatory T (Treg) cells can induce senescence of tumour-associated effector T cells, but it is not clear how. Here the authors show that Treg cells outcompete effector T cells for glucose uptake, resulting in activation of the DNA damage response in effector T cells.