Nature Communications (Nov 2017)

DNA methylation signatures follow preformed chromatin compartments in cardiac myocytes

  • Stephan Nothjunge,
  • Thomas G. Nührenberg,
  • Björn A. Grüning,
  • Stefanie A. Doppler,
  • Sebastian Preissl,
  • Martin Schwaderer,
  • Carolin Rommel,
  • Markus Krane,
  • Lutz Hein,
  • Ralf Gilsbach

DOI
https://doi.org/10.1038/s41467-017-01724-9
Journal volume & issue
Vol. 8, no. 1
pp. 1 – 9

Abstract

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Chromatin is organized in higher order A and B compartments, reflecting active and inactive chromatin. Here, the authors provide evidence that in cardiac myocytes DNA methylation is established in preformed chromatin compartments and may be dispensable for higher order chromatin organization.