The Role of CLEC-2 and Its Ligands in Thromboinflammation

Danyang Meng; Man Luo; Beibei Liu

doi:10.3389/fimmu.2021.688643

Frontiers in Immunology (Jun 2021)

The Role of CLEC-2 and Its Ligands in Thromboinflammation

Danyang Meng,
Man Luo,
Beibei Liu

Affiliations

Danyang Meng: Department of Neurology, Affiliated Hospital of Jiaxing University, Jiaxing, China
Man Luo: Department of Neurology, Affiliated Hospital of Jiaxing University, Jiaxing, China
Beibei Liu: Department of Central Laboratory, Affiliated Hospital of Jiaxing University, Jiaxing, China

DOI: https://doi.org/10.3389/fimmu.2021.688643
Journal volume & issue: Vol. 12

Abstract

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C-type lectin-like receptor 2 (CLEC-2, also known as CLEC-1b) is expressed on platelets, Kupffer cells and other immune cells, and binds to various ligands including the mucin-like protein podoplanin (PDPN). The role of CLEC-2 in infection and immunity has become increasingly evident in recent years. CLEC-2 is involved in platelet activation, tumor cell metastasis, separation of blood/lymphatic vessels, and cerebrovascular patterning during embryonic development. In this review, we have discussed the role of CLEC-2 in thromboinflammation, and focused on the recent research.

Published in Frontiers in Immunology

ISSN: 1664-3224 (Online)
Publisher: Frontiers Media S.A.
Country of publisher: Switzerland
LCC subjects: Medicine: Internal medicine: Specialties of internal medicine: Immunologic diseases. Allergy
Website: http://journal.frontiersin.org/journal/immunology

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