Italian Journal of Animal Science (Mar 2011)

In vitro evaluation of cytotoxicity and oxidative damage induced by ochratoxin A and aflatoxin B1: protective role of antioxidants

  • F. Cheli,
  • B. Bertasi,
  • E. Pavoni,
  • R. Rebucci,
  • N. Losio,
  • L. Sangalli,
  • E. Fusi,
  • A. Baldi

DOI
https://doi.org/10.4081/ijas.2003.s1.231
Journal volume & issue
Vol. 2, no. 1S
pp. 231 – 233

Abstract

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In animal nutrition, mycotoxins are important feed contaminants. Among them, ochratoxins (OTA) and aflatoxins (AF) have several biological activities, including acute toxicity, teratogenicity, mutagenicity, immunotoxicity and carcinogenicity (Creepy, 2002). Obviously, toxicity of mycotoxins is a risk factor not only for animals but for humans, too (Hussein et al., 2001). Deficiencies of certain nutritional factors e.g. micronutrients may predispose or enhance individuals to the toxic effects of mycotoxins (Atroshi et al., 2002). It is well known that antioxidants like vitamin E, protect cellular membranes from oxidative damage.........

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