Study of cell adhesion, osteogenesis, and angiogenesis of a “groove” structure micro-arc oxidation titanium

Yifan Fei; Wenyi Yang; Zhaoyang Guo; Haishui Sun; Fan Yang; Jingzhou Hu

Applied Surface Science Advances (Feb 2024)

Study of cell adhesion, osteogenesis, and angiogenesis of a “groove” structure micro-arc oxidation titanium

Yifan Fei,
Wenyi Yang,
Zhaoyang Guo,
Haishui Sun,
Fan Yang,
Jingzhou Hu

Affiliations

Yifan Fei: Department of Oral & Maxillofacial-Head & Neck Oncology, Shanghai Jiao Tong University School of Medicine Affiliated Ninth People's Hospital, China; Shanghai International Medical Center, China
Wenyi Yang: Department of Oral & Maxillofacial-Head & Neck Oncology, Shanghai Jiao Tong University School of Medicine Affiliated Ninth People's Hospital, China
Zhaoyang Guo: Department of Oral & Maxillofacial-Head & Neck Oncology, Shanghai Jiao Tong University School of Medicine Affiliated Ninth People's Hospital, China
Haishui Sun: Department of Oral & Maxillofacial-Head & Neck Oncology, Shanghai Jiao Tong University School of Medicine Affiliated Ninth People's Hospital, China; Corresponding author at: Department of Oral Head & Neck Oncology, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine; College of Stomatology, Shanghai Jiao Tong University; National Center for Stomatology; National Clinical Research Center for Oral Diseases; Shanghai Key Laboratory of Stomatology; Shanghai Research Institute of Stomatology, Shanghai, 200011, China.
Fan Yang: School of Physical Science and Technology, ShanghaiTech University, China; Corresponding author at: Department of Oral Head & Neck Oncology, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine; College of Stomatology, Shanghai Jiao Tong University; National Center for Stomatology; National Clinical Research Center for Oral Diseases; Shanghai Key Laboratory of Stomatology; Shanghai Research Institute of Stomatology, Shanghai, 200011, China.
Jingzhou Hu: Department of Oral & Maxillofacial-Head & Neck Oncology, Shanghai Jiao Tong University School of Medicine Affiliated Ninth People's Hospital, China; Corresponding author at: Department of Oral Head & Neck Oncology, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine; College of Stomatology, Shanghai Jiao Tong University; National Center for Stomatology; National Clinical Research Center for Oral Diseases; Shanghai Key Laboratory of Stomatology; Shanghai Research Institute of Stomatology, Shanghai, 200011, China.

Journal volume & issue: Vol. 19
p. 100552

Abstract

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The use of titanium alloy-based dental implant restorations has gained popularity due to their attractive properties. Current research on the surface modification of titanium materials primarily centers around the surface integration of various metal ions, the incorporation of different drugs, or other materials. By simply adjusting the process parameters of micro-arc oxidation, we were able to form a “groove” structure in titanium chips. Scanning Electron Microscopy (SEM) observations revealed that Bone Marrow Stem Cells (BMSCs) noticeably elongated along the “grooves”. Immunofluorescence results indicated an elevated expression of Osteocalcin (OCN) and CD31 in “groove” structure group. Furthermore, “groove” structure group also amplified the expression of osteogenic genes (Alkaline Phosphatase, ALP; Osteocalcin, OCN) and angiogenic genes (CD31, Vascular Endothelial Growth Factor, VEGF; Angiopoietin-2, ANG2; and Fibroblast Growth Factor, FGF) on the material surface (P < 0.05). This study suggests that the “groove” structure enhances early cell adhesion on the material surface and improves osteogenic and angiogenic differentiation on the titanium surface, thereby providing potential research implications for enhancing the initial stability of implants.

Published in Applied Surface Science Advances

ISSN: 2666-5239 (Online)
Publisher: Elsevier
Country of publisher: Netherlands
LCC subjects: Technology: Electrical engineering. Electronics. Nuclear engineering: Materials of engineering and construction. Mechanics of materials; Technology: Chemical technology: Industrial electrochemistry
Website: https://www.journals.elsevier.com/applied-surface-science-advances

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