Additional New Cytotoxic Triquinane-Type Sesquiterpenoids Chondrosterins K–M from the Marine Fungus Chondrostereum sp.
Lei Huang,
Wen-Jian Lan,
Rong Deng,
Gong-Kan Feng,
Qing-Yan Xu,
Zhi-Yu Hu,
Xiao-Feng Zhu,
Hou-Jin Li
Affiliations
Lei Huang
School of Chemistry and Chemical Engineering, Sun Yat-sen University, Guangzhou 510275, China
Wen-Jian Lan
School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, China
Rong Deng
State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Cancer Center, Sun Yat-sen University, Guangzhou 510060, China
Gong-Kan Feng
State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Cancer Center, Sun Yat-sen University, Guangzhou 510060, China
Qing-Yan Xu
School of Life Sciences, Xiamen University, Xiamen 361102, China
Zhi-Yu Hu
School of Life Sciences, Xiamen University, Xiamen 361102, China
Xiao-Feng Zhu
State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Cancer Center, Sun Yat-sen University, Guangzhou 510060, China
Hou-Jin Li
School of Chemistry and Chemical Engineering, Sun Yat-sen University, Guangzhou 510275, China
By the method of 1H NMR prescreening and tracing the diagnostic proton signals of the methyl groups, three additional new triquinane-type sesquiterpenoids—chondrosterins K–M (1–3) and the known sesquiterpenoid anhydroarthrosporone (4)—were isolated from the marine fungus Chondrostereum sp. Their structures were elucidated on the basis of MS, 1D, and 2D NMR data. Chondrosterin K is a rare hirsutane sesquiterpenoid, in which a methyl group was migrated from C-2 to C-6 and has a double bond between C-2 and C-3. Compounds 1–3 showed significant cytotoxicities against various cancer cell lines in vitro.
