Nature Communications (Apr 2019)
Genome-wide association study of alcohol consumption and use disorder in 274,424 individuals from multiple populations
- Henry R. Kranzler,
- Hang Zhou,
- Rachel L. Kember,
- Rachel Vickers Smith,
- Amy C. Justice,
- Scott Damrauer,
- Philip S. Tsao,
- Derek Klarin,
- Aris Baras,
- Jeffrey Reid,
- John Overton,
- Daniel J. Rader,
- Zhongshan Cheng,
- Janet P. Tate,
- William C. Becker,
- John Concato,
- Ke Xu,
- Renato Polimanti,
- Hongyu Zhao,
- Joel Gelernter
Affiliations
- Henry R. Kranzler
- University of Pennsylvania Perelman School of Medicine
- Hang Zhou
- Yale School of Medicine
- Rachel L. Kember
- University of Pennsylvania Perelman School of Medicine
- Rachel Vickers Smith
- Crescenz Veterans Affairs Medical Center
- Amy C. Justice
- Yale School of Medicine
- Scott Damrauer
- University of Pennsylvania Perelman School of Medicine
- Philip S. Tsao
- VA Palo Alto Health Care System
- Derek Klarin
- Massachusetts General Hospital, Harvard Medical School
- Aris Baras
- Regeneron Genetics Center
- Jeffrey Reid
- Regeneron Genetics Center
- John Overton
- Regeneron Genetics Center
- Daniel J. Rader
- University of Pennsylvania Perelman School of Medicine
- Zhongshan Cheng
- Yale School of Medicine
- Janet P. Tate
- Yale School of Medicine
- William C. Becker
- Yale School of Medicine
- John Concato
- Yale School of Medicine
- Ke Xu
- Yale School of Medicine
- Renato Polimanti
- Yale School of Medicine
- Hongyu Zhao
- Yale School of Medicine
- Joel Gelernter
- Yale School of Medicine
- DOI
- https://doi.org/10.1038/s41467-019-09480-8
- Journal volume & issue
-
Vol. 10,
no. 1
pp. 1 – 11
Abstract
The genetic underpinnings of alcohol use disorder and consumption are incompletely understood. Here, the authors perform GWAS for Alcohol Use Disorder (AUD) Identification Test-Consumption scores and AUD diagnosis from electronic health records of 274,424 individuals and identify a total of 18 associated loci.
