Lomitapide repurposing for treatment of malignancies: A promising direction
Hua-Tao Wu,
Bing-Xuan Wu,
Ze-Xuan Fang,
Zheng Wu,
Yan-Yu Hou,
Yu Deng,
Yu-Kun Cui,
Jing Liu
Affiliations
Hua-Tao Wu
Department of General Surgery, the First Affiliated Hospital of Shantou University Medical College, Shantou, 515041, China; The Breast Center, Cancer Hospital of Shantou University Medical College, Shantou, 515041, China
Bing-Xuan Wu
Department of General Surgery, the First Affiliated Hospital of Shantou University Medical College, Shantou, 515041, China; The Breast Center, Cancer Hospital of Shantou University Medical College, Shantou, 515041, China
Ze-Xuan Fang
The Breast Center, Cancer Hospital of Shantou University Medical College, Shantou, 515041, China; Department of Physiology/Changjiang Scholar's Laboratory, Shantou University Medical College, Shantou, 515041, China
Zheng Wu
The Breast Center, Cancer Hospital of Shantou University Medical College, Shantou, 515041, China; Department of Physiology/Changjiang Scholar's Laboratory, Shantou University Medical College, Shantou, 515041, China
Yan-Yu Hou
The Breast Center, Cancer Hospital of Shantou University Medical College, Shantou, 515041, China; Department of Physiology/Changjiang Scholar's Laboratory, Shantou University Medical College, Shantou, 515041, China
Yu Deng
Department of General Surgery, the First Affiliated Hospital of Shantou University Medical College, Shantou, 515041, China; The Breast Center, Cancer Hospital of Shantou University Medical College, Shantou, 515041, China
Yu-Kun Cui
The Breast Center, Cancer Hospital of Shantou University Medical College, Shantou, 515041, China; Corresponding author.
Jing Liu
The Breast Center, Cancer Hospital of Shantou University Medical College, Shantou, 515041, China; Department of Physiology/Changjiang Scholar's Laboratory, Shantou University Medical College, Shantou, 515041, China; Corresponding author. The Breast Center, Cancer Hospital of Shantou University Medical College, Shantou 515041, China.
The development of novel drugs from basic science to clinical practice requires several years, much effort, and cost. Drug repurposing can promote the utilization of clinical drugs in cancer therapy. Recent studies have shown the potential effects of lomitapide on treating malignancies, which is currently used for the treatment of familial hypercholesterolemia. We systematically review possible functions and mechanisms of lomitapide as an anti-tumor compound, regarding the aspects of apoptosis, autophagy, and metabolism of tumor cells, to support repurposing lomitapide for the clinical treatment of tumors.
