COVID-19 patients and Dementia: Frontal cortex transcriptomic data
Maria Garofalo,
Stella Gagliardi,
Susanna Zucca,
Cecilia Pandini,
Francesca Dragoni,
Daisy Sproviero,
Orietta Pansarasa,
Tino Emanuele Poloni,
Valentina Medici,
Annalisa Davin,
Silvia Damiana Visonà,
Matteo Moretti,
Antonio Guaita,
Mauro Ceroni,
Livio Tronconi,
Cristina Cereda
Affiliations
Maria Garofalo
Genomic and post-Genomic Unit, IRCCS Mondino Foundation, Via Mondino, 2, Pavia 27100, Italy; Department of Biology and Biotechnology ''L. Spallanzani'', University of Pavia, Pavia, Italy
Stella Gagliardi
Genomic and post-Genomic Unit, IRCCS Mondino Foundation, Via Mondino, 2, Pavia 27100, Italy
Susanna Zucca
EnGenome SRL, Pavia 27100, Italy
Cecilia Pandini
Genomic and post-Genomic Unit, IRCCS Mondino Foundation, Via Mondino, 2, Pavia 27100, Italy
Francesca Dragoni
Genomic and post-Genomic Unit, IRCCS Mondino Foundation, Via Mondino, 2, Pavia 27100, Italy; Department of Biology and Biotechnology ''L. Spallanzani'', University of Pavia, Pavia, Italy
Daisy Sproviero
Genomic and post-Genomic Unit, IRCCS Mondino Foundation, Via Mondino, 2, Pavia 27100, Italy
Orietta Pansarasa
Genomic and post-Genomic Unit, IRCCS Mondino Foundation, Via Mondino, 2, Pavia 27100, Italy
Tino Emanuele Poloni
Department of Neurology and Neuropathology, Golgi-Cenci Foundation & ASP Golgi-Redaelli Abbiategrasso, Milano, Italy
Valentina Medici
Department of Neurology and Neuropathology, Golgi-Cenci Foundation & ASP Golgi-Redaelli Abbiategrasso, Milano, Italy
Annalisa Davin
Department of Neurology and Neuropathology, Golgi-Cenci Foundation & ASP Golgi-Redaelli Abbiategrasso, Milano, Italy
Silvia Damiana Visonà
Department of Public Health, Experimental and Forensic Medicine, Unit of Legal Medicine and Forensic Sciences “A. Fornari”, University of Pavia, Pavia, Italy
Matteo Moretti
Department of Public Health, Experimental and Forensic Medicine, Unit of Legal Medicine and Forensic Sciences “A. Fornari”, University of Pavia, Pavia, Italy
Antonio Guaita
Department of Neurology and Neuropathology, Golgi-Cenci Foundation & ASP Golgi-Redaelli Abbiategrasso, Milano, Italy
Mauro Ceroni
Department of Brain and Behavioral Sciences, University of Pavia, Pavia, Italy; Department of General Neurology, IRCCS Mondino Foundation, Pavia, Italy
Livio Tronconi
Department of Public Health, Experimental and Forensic Medicine, Unit of Legal Medicine and Forensic Sciences “A. Fornari”, University of Pavia, Pavia, Italy; U.O. Medicina Legale, IRCCS Mondino Foundation, Pavia, Italy
Cristina Cereda
Genomic and post-Genomic Unit, IRCCS Mondino Foundation, Via Mondino, 2, Pavia 27100, Italy; Corresponding author.
Since the association of SARS-Cov-2 infection with Nervous System (NS) manifestations, we performed RNA-sequencing analysis in Frontal Cortex of COVID-19 positive or negative individuals and affected or not by Dementia individuals. We examined gene expression differences in individuals with COVID-19 and Dementia compared to Dementia only patients by collecting transcript counts in each sample and performing Differential Expression analysis. We found eleven genes satisfying our significance criteria, all of them being protein coding genes.These data are suitable for integration with supplemental samples and for analysis according to different individuals’ classification. Also, differential expression evaluation may be implemented with other scientific purposes, such as research of unannotated genes, mRNA splicing and genes isoforms.The analysis of Differential Expressed genes in COVID-19 positive patients compared to non-COVID-19 patients is published in: S. Gagliardi, E.T. Poloni, C. Pandini, M. Garofalo, F. Dragoni, V. Medici, A. Davin, S.D. Visonà, M. Moretti, D. Sproviero, O. Pansarasa, A. Guaita, M. Ceroni, L. Tronconi, C. Cereda, Detection of SARS-CoV-2 genome and whole transcriptome sequencing in frontal cortex of COVID-19 patients., Brain. Behav. Immun. (2021). https://doi.org/10.1016/j.bbi.2021.05.012.
