In Vitro Comparison of Biological Effects of Coe-Pak and Reso-Pac Periodontal Dressings

Abstract

Objectives: The purpose of the present study was to compare the cytotoxicity of Reso-Pac and Coe-Pak periodontal dressing. Material and Methods: According to ISO-10993-12:2012, 1-, 3- and 7-day extracts of the two periodontal dressings were prepared in cell culture medium and exposed to the two cultured cell lines. Cell viability and proliferation at 24 h and 72 h following exposure were evaluated using quantitative MTT assay. Results: The results showed a significant (P 0.05) difference was found in the viability of cells exposed to undiluted (100%) one-day extract and diluted (50%) extract of both understudy materials at 24 h and 72 h after exposure. Conclusions: Based on the results, Reso-Pac periodontal dressing has less cytotoxicity than Coe-Pak.

Keywords

• fibroblasts
• materials testing
• osteoblasts
• periodontal dressings