Nature Communications (Oct 2021)

Next generation of tumor-activating type I IFN enhances anti-tumor immune responses to overcome therapy resistance

  • Xuezhi Cao,
  • Yong Liang,
  • Zhenxiang Hu,
  • Huiyu Li,
  • Jiaming Yang,
  • Eric J. Hsu,
  • Jiankun Zhu,
  • Jin Zhou,
  • Yang-Xin Fu

DOI
https://doi.org/10.1038/s41467-021-26112-2
Journal volume & issue
Vol. 12, no. 1
pp. 1 – 11

Abstract

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Several studies have demonstrated that IFN-I administration can boost anti-tumor immune response against solid tumors. Here, to overcome the limitations of systemic IFN-I therapy (side effects, short half-life), the authors design a masked IFN-I prodrug activatable by tumor-associated proteases, showing preserved anti-tumor activity but reduced toxicity.