Structure of a nucleosome-bound MuvB transcription factor complex reveals DNA remodelling

Abstract

The MuvB family of protein complexes regulate cell cycle-dependent transcription, and MuvB in complex with the transcription factors B-MYB and FOXM1 activate mitotic genes during G2. Here the authors present cryo-EM data of a MuvB:B-MYB (MMB) complex in the process of remodelling a nucleosome, and define its stoichiometry, assembly, and chromatin binding.