A ribosomally synthesised and post-translationally modified peptide containing a β-enamino acid and a macrocyclic motif

Shan Wang; Sixing Lin; Qing Fang; Roland Gyampoh; Zhou Lu; Yingli Gao; David J. Clarke; Kewen Wu; Laurent Trembleau; Yi Yu; Kwaku Kyeremeh; Bruce F. Milne; Jioji Tabudravu; Hai Deng

doi:10.1038/s41467-022-32774-3

Nature Communications (Aug 2022)

A ribosomally synthesised and post-translationally modified peptide containing a β-enamino acid and a macrocyclic motif

Shan Wang,
Sixing Lin,
Qing Fang,
Roland Gyampoh,
Zhou Lu,
Yingli Gao,
David J. Clarke,
Kewen Wu,
Laurent Trembleau,
Yi Yu,
Kwaku Kyeremeh,
Bruce F. Milne,
Jioji Tabudravu,
Hai Deng

Affiliations

Shan Wang: Department of Chemistry, University of Aberdeen
Sixing Lin: Key Laboratory of Combinatorial Biosynthesis and Drug Discovery (MOE) and Hubei Province Engineering and Technology Research Centre for Fluorinated Pharmaceuticals, School of Pharmaceutical Sciences, Wuhan University
Qing Fang: Department of Chemistry, University of Aberdeen
Roland Gyampoh: Department of Chemistry, University of Ghana
Zhou Lu: Department of Chemistry, University of Aberdeen
Yingli Gao: Department of Chemistry, University of Aberdeen
David J. Clarke: EastChem, School of Chemistry, University of Edinburgh
Kewen Wu: Department of Chemistry, University of Aberdeen
Laurent Trembleau: Department of Chemistry, University of Aberdeen
Yi Yu: Key Laboratory of Combinatorial Biosynthesis and Drug Discovery (MOE) and Hubei Province Engineering and Technology Research Centre for Fluorinated Pharmaceuticals, School of Pharmaceutical Sciences, Wuhan University
Kwaku Kyeremeh: Department of Chemistry, University of Ghana
Bruce F. Milne: Department of Chemistry, University of Aberdeen
Jioji Tabudravu: School of Natural Sciences, University of Central Lancashire
Hai Deng: Department of Chemistry, University of Aberdeen

DOI: https://doi.org/10.1038/s41467-022-32774-3
Journal volume & issue: Vol. 13, no. 1
pp. 1 – 15

Abstract

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The chemical diversity of peptides from ribosomal origin is a growing field of research. Here, the authors report the discovery, genomic and biosynthetic investigations of kintamdin, a ribosomally synthesized and post-translationally modified peptides featuring a beta-enamino acid and a bis-thioether macrocyclic motif.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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