Involvement of Il-33 in the Pathogenesis and Prognosis of Major Respiratory Viral Infections: Future Perspectives for Personalized Therapy
Giuseppe Murdaca,
Francesca Paladin,
Alessandro Tonacci,
Matteo Borro,
Monica Greco,
Alessandra Gerosa,
Stefania Isola,
Alessandro Allegra,
Sebastiano Gangemi
Affiliations
Giuseppe Murdaca
Department of Internal Medicine, Ospedale Policlinico San Martino, 16132 Genoa, Italy
Francesca Paladin
Department of Internal Medicine, Ospedale Policlinico San Martino, 16132 Genoa, Italy
Alessandro Tonacci
Clinical Physiology Institute, National Research Council of Italy (IFC-CNR), 56124 Pisa, Italy
Matteo Borro
Internal Medicine Department, San Paolo Hospital, 17100 Savona, Italy
Monica Greco
Internal Medicine Department, San Paolo Hospital, 17100 Savona, Italy
Alessandra Gerosa
Department of Internal Medicine, Ospedale Policlinico San Martino, 16132 Genoa, Italy
Stefania Isola
Department of Clinical and Experimental Medicine, School and Operative Unit of Allergy and Clinical Immunology, University of Messina, 98125 Messina, Italy
Alessandro Allegra
Department of Human Pathology in Adulthood and Childhood “Gaetano Barresi”, Division of Hematology, University of Messina, 98125 Messina, Italy
Sebastiano Gangemi
Department of Clinical and Experimental Medicine, School and Operative Unit of Allergy and Clinical Immunology, University of Messina, 98125 Messina, Italy
Interleukin (IL)-33 is a key cytokine involved in type-2 immunity and allergic airway disease. At the level of lung epithelial cells, where it is clearly expressed, IL-33 plays an important role in both innate and adaptive immune responses in mucosal organs. It has been widely demonstrated that in the course of respiratory virus infections, the release of IL-33 increases, with consequent pro-inflammatory effects and consequent exacerbation of the clinical symptoms of chronic respiratory diseases. In our work, we analyzed the pathogenetic and prognostic involvement of IL-33 during the main respiratory viral infections, with particular interest in the recent SARS-CoV-2virus pandemic and the aim of determining a possible connection point on which to act with a targeted therapy that is able to improve the clinical outcome of patients.
