Nature Communications (Jan 2020)

Constitutively bound CTCF sites maintain 3D chromatin architecture and long-range epigenetically regulated domains

  • Amanda Khoury,
  • Joanna Achinger-Kawecka,
  • Saul A. Bert,
  • Grady C. Smith,
  • Hugh J. French,
  • Phuc-Loi Luu,
  • Timothy J. Peters,
  • Qian Du,
  • Aled J. Parry,
  • Fatima Valdes-Mora,
  • Phillippa C. Taberlay,
  • Clare Stirzaker,
  • Aaron L. Statham,
  • Susan J. Clark

DOI
https://doi.org/10.1038/s41467-019-13753-7
Journal volume & issue
Vol. 11, no. 1
pp. 1 – 13

Abstract

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The architectural protein CTCF is a mediator of chromatin conformation, but how CTCF binding to DNA is regulated remains poorly understood. Here the authors find that there is a shared subset of CTCF-bound sites resistant to protein depletion in different cell lines, which are enriched at domain boundaries and chromatin loops constitutive to all cell types.