Levels of serum IL-1β, IL-2, IL-8 and tumor necrosis factor-α in patients with unstable angina pectoris

Abstract

Objectives: Inflammation is the most important mechanism of plaque disruption playing an essential role in acute coronary syndromes. It is controversial whether the inflammatory mediators are the cause or the result in the development of plaque rupture. Stimulation of interleukins increases adhesion molecules, fibrinogen and plasminogen activator inhibitors, which cause the activation of inflammation and thrombosis. However, the importance of interleukins in acute coronary syndromes has not been clearly defined. We did not find any article concerning relations between the levels of serum interleukin (IL)-1β, IL-2, IL -8 and tumor necrosis factor (TNF)-α in patients with unstable angina pectoris (UAP). So the aim of this study was to determine the levels of serum IL-1β, IL-2, IL-8 and TNF-α during the early stage of UAP.

Keywords

• Unstable angina pectoris
• Inflammation
• Interleukins.