Communications Biology (Jan 2023)
Role of miR-944/MMP10/AXL- axis in lymph node metastasis in tongue cancer
- Bhasker Dharavath,
- Ashwin Butle,
- Ankita Pal,
- Sanket Desai,
- Pawan Upadhyay,
- Aishwarya Rane,
- Risha Khandelwal,
- Sujith Manavalan,
- Rahul Thorat,
- Kavita Sonawane,
- Richa Vaish,
- Poonam Gera,
- Munita Bal,
- Anil K. D’Cruz,
- Sudhir Nair,
- Amit Dutt
Affiliations
- Bhasker Dharavath
- Integrated Cancer Genomics Laboratory, Advanced Centre for Treatment, Research, and Education in Cancer, Kharghar
- Ashwin Butle
- Integrated Cancer Genomics Laboratory, Advanced Centre for Treatment, Research, and Education in Cancer, Kharghar
- Ankita Pal
- Integrated Cancer Genomics Laboratory, Advanced Centre for Treatment, Research, and Education in Cancer, Kharghar
- Sanket Desai
- Integrated Cancer Genomics Laboratory, Advanced Centre for Treatment, Research, and Education in Cancer, Kharghar
- Pawan Upadhyay
- Integrated Cancer Genomics Laboratory, Advanced Centre for Treatment, Research, and Education in Cancer, Kharghar
- Aishwarya Rane
- Integrated Cancer Genomics Laboratory, Advanced Centre for Treatment, Research, and Education in Cancer, Kharghar
- Risha Khandelwal
- Integrated Cancer Genomics Laboratory, Advanced Centre for Treatment, Research, and Education in Cancer, Kharghar
- Sujith Manavalan
- Integrated Cancer Genomics Laboratory, Advanced Centre for Treatment, Research, and Education in Cancer, Kharghar
- Rahul Thorat
- Laboratory Animal Facility, Advanced Centre for Treatment, Research and Education in Cancer, Kharghar
- Kavita Sonawane
- Division of Head and Neck Oncology, Department of Surgical Oncology, Tata Memorial Hospital, Tata Memorial Centre, Parel
- Richa Vaish
- Homi Bhabha National Institute, Training School Complex, Anushakti Nagar
- Poonam Gera
- Homi Bhabha National Institute, Training School Complex, Anushakti Nagar
- Munita Bal
- Homi Bhabha National Institute, Training School Complex, Anushakti Nagar
- Anil K. D’Cruz
- Division of Head and Neck Oncology, Department of Surgical Oncology, Tata Memorial Hospital, Tata Memorial Centre, Parel
- Sudhir Nair
- Homi Bhabha National Institute, Training School Complex, Anushakti Nagar
- Amit Dutt
- Integrated Cancer Genomics Laboratory, Advanced Centre for Treatment, Research, and Education in Cancer, Kharghar
- DOI
- https://doi.org/10.1038/s42003-023-04437-6
- Journal volume & issue
-
Vol. 6,
no. 1
pp. 1 – 12
Abstract
MMP10, which is upregulated in 86% of primary tongue tumors with lymph node metastases, is negatively regulated by miR-944 and promotes nodal metastasis in an orthotopic tongue cancer mouse model through the AXL signaling pathway.
