A T-cell receptor escape channel allows broad T-cell response to CD1b and membrane phospholipids

Adam Shahine; Peter Reinink; Josephine F. Reijneveld; Stephanie Gras; Mira Holzheimer; Tan-Yun Cheng; Adriaan J. Minnaard; John D. Altman; Steffi Lenz; Jacques Prandi; Joanna Kubler-Kielb; D. Branch Moody; Jamie Rossjohn; Ildiko Van Rhijn

doi:10.1038/s41467-018-07898-0

Nature Communications (Jan 2019)

A T-cell receptor escape channel allows broad T-cell response to CD1b and membrane phospholipids

Adam Shahine,
Peter Reinink,
Josephine F. Reijneveld,
Stephanie Gras,
Mira Holzheimer,
Tan-Yun Cheng,
Adriaan J. Minnaard,
John D. Altman,
Steffi Lenz,
Jacques Prandi,
Joanna Kubler-Kielb,
D. Branch Moody,
Jamie Rossjohn,
Ildiko Van Rhijn

Affiliations

Adam Shahine: Infection and Immunity Program and Department of Biochemistry and Molecular Biology, Biomedicine Discovery Institute, Monash University
Peter Reinink: Department of Infectious Diseases and Immunology, Faculty of Veterinary Medicine, Utrecht University
Josephine F. Reijneveld: Department of Infectious Diseases and Immunology, Faculty of Veterinary Medicine, Utrecht University
Stephanie Gras: Infection and Immunity Program and Department of Biochemistry and Molecular Biology, Biomedicine Discovery Institute, Monash University
Mira Holzheimer: Stratingh Institute for Chemistry, University of Groningen
Tan-Yun Cheng: Brigham and Women’s Hospital Division of Rheumatology, Immunology and Allergy and Harvard Medical School
Adriaan J. Minnaard: Stratingh Institute for Chemistry, University of Groningen
John D. Altman: Department of Microbiology and Immunology, Emory University School of Medicine
Steffi Lenz: Department of Infectious Diseases and Immunology, Faculty of Veterinary Medicine, Utrecht University
Jacques Prandi: Institut de Pharmacologie et de Biologie Structurale, Université de Toulouse, CNRS, Université Paul Sabatier
Joanna Kubler-Kielb: National Institute of Child Health and Human Development, National Institutes of Health
D. Branch Moody: Brigham and Women’s Hospital Division of Rheumatology, Immunology and Allergy and Harvard Medical School
Jamie Rossjohn: Infection and Immunity Program and Department of Biochemistry and Molecular Biology, Biomedicine Discovery Institute, Monash University
Ildiko Van Rhijn: Department of Infectious Diseases and Immunology, Faculty of Veterinary Medicine, Utrecht University

DOI: https://doi.org/10.1038/s41467-018-07898-0
Journal volume & issue: Vol. 10, no. 1
pp. 1 – 12

Abstract

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CD1 proteins present lipid antigens to T cells via the T cell receptor. Here the authors describe T cell reactivity to human membrane lipid moieties and provide structural data to define a molecular mechanism of promiscuous recognition of self-derived phospholipids.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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