Consistent tumorigenesis with self-assembled hydrogels enables high-powered murine cancer studies

Abigail K. Grosskopf; Santiago Correa; Julie Baillet; Caitlin L. Maikawa; Emily C. Gale; Ryanne A. Brown; Eric A. Appel

doi:10.1038/s42003-021-02500-8

Communications Biology (Aug 2021)

Consistent tumorigenesis with self-assembled hydrogels enables high-powered murine cancer studies

Abigail K. Grosskopf,
Santiago Correa,
Julie Baillet,
Caitlin L. Maikawa,
Emily C. Gale,
Ryanne A. Brown,
Eric A. Appel

Affiliations

Abigail K. Grosskopf: Department of Chemical Engineering, Stanford University
Santiago Correa: Department of Materials Science and Engineering, Stanford University
Julie Baillet: Department of Materials Science and Engineering, Stanford University
Caitlin L. Maikawa: Department of Bioengineering, Stanford University
Emily C. Gale: Department of Biochemistry, Stanford University
Ryanne A. Brown: Department of Pathology, Stanford University School of Medicine
Eric A. Appel: Department of Materials Science and Engineering, Stanford University

DOI: https://doi.org/10.1038/s42003-021-02500-8
Journal volume & issue: Vol. 4, no. 1
pp. 1 – 7

Abstract

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Grosskopf et al. report the development of a tumor inoculation method using self-assembled alginate hydrogels containing different tumorigenic molecules to reproducibly generate tumors in a subcutaneous murine tumor model. They show the impact of this improved model on the reduction of cohort size and increase in the power of the study design.

Published in Communications Biology

ISSN: 2399-3642 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science: Biology (General)
Website: https://www.nature.com/commsbio/

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