Nature Communications (Mar 2019)
Genome-wide association study identifies genetic loci for self-reported habitual sleep duration supported by accelerometer-derived estimates
- Hassan S. Dashti,
- Samuel E. Jones,
- Andrew R. Wood,
- Jacqueline M. Lane,
- Vincent T. van Hees,
- Heming Wang,
- Jessica A. Rhodes,
- Yanwei Song,
- Krunal Patel,
- Simon G. Anderson,
- Robin N. Beaumont,
- David A. Bechtold,
- Jack Bowden,
- Brian E. Cade,
- Marta Garaulet,
- Simon D. Kyle,
- Max A. Little,
- Andrew S. Loudon,
- Annemarie I. Luik,
- Frank A. J. L. Scheer,
- Kai Spiegelhalder,
- Jessica Tyrrell,
- Daniel J. Gottlieb,
- Henning Tiemeier,
- David W. Ray,
- Shaun M. Purcell,
- Timothy M. Frayling,
- Susan Redline,
- Deborah A. Lawlor,
- Martin K. Rutter,
- Michael N. Weedon,
- Richa Saxena
Affiliations
- Hassan S. Dashti
- Center for Genomic Medicine, Massachusetts General Hospital and Harvard Medical School
- Samuel E. Jones
- Genetics of Complex Traits, University of Exeter Medical School
- Andrew R. Wood
- Genetics of Complex Traits, University of Exeter Medical School
- Jacqueline M. Lane
- Center for Genomic Medicine, Massachusetts General Hospital and Harvard Medical School
- Vincent T. van Hees
- Netherlands eScience Center
- Heming Wang
- Broad Institute
- Jessica A. Rhodes
- Center for Genomic Medicine, Massachusetts General Hospital and Harvard Medical School
- Yanwei Song
- Center for Genomic Medicine, Massachusetts General Hospital and Harvard Medical School
- Krunal Patel
- Center for Genomic Medicine, Massachusetts General Hospital and Harvard Medical School
- Simon G. Anderson
- Division of Cardiovascular Sciences, School of Medical Sciences, Faculty of Biology, Medicine and Health, The University of Manchester
- Robin N. Beaumont
- Genetics of Complex Traits, University of Exeter Medical School
- David A. Bechtold
- Division of Endocrinology, Diabetes & Gastroenterology, School of Medical Sciences, Faculty of Biology, Medicine and Health, University of Manchester
- Jack Bowden
- MRC Integrative Epidemiology Unit at the University of Bristol
- Brian E. Cade
- Broad Institute
- Marta Garaulet
- Department of Physiology, University of Murcia
- Simon D. Kyle
- Sleep and Circadian Neuroscience Institute, Nuffield Department of Clinical Neurosciences, University of Oxford
- Max A. Little
- Department of Mathematics, Aston University
- Andrew S. Loudon
- Division of Endocrinology, Diabetes & Gastroenterology, School of Medical Sciences, Faculty of Biology, Medicine and Health, University of Manchester
- Annemarie I. Luik
- Sleep and Circadian Neuroscience Institute, Nuffield Department of Clinical Neurosciences, University of Oxford
- Frank A. J. L. Scheer
- Broad Institute
- Kai Spiegelhalder
- Clinic for Psychiatry and Psychotherapy, Medical Centre - University of Freiburg, Faculty of Medicine, University of Freiburg
- Jessica Tyrrell
- Genetics of Complex Traits, University of Exeter Medical School
- Daniel J. Gottlieb
- Division of Sleep and Circadian Disorders, Department of Medicine, Brigham and Women’s Hospital
- Henning Tiemeier
- Deprtment of Social and Behavioral Science, Harvard TH Chan School of Public Health
- David W. Ray
- Division of Endocrinology, Diabetes & Gastroenterology, School of Medical Sciences, Faculty of Biology, Medicine and Health, University of Manchester
- Shaun M. Purcell
- Department of Psychiatry, Brigham & Women’s Hospital, Harvard Medical School
- Timothy M. Frayling
- Genetics of Complex Traits, University of Exeter Medical School
- Susan Redline
- Departments of Medicine, Brigham and Women’s Hospital and Beth Israel Deaconess Medical Center, Harvard Medical School
- Deborah A. Lawlor
- MRC Integrative Epidemiology Unit at the University of Bristol
- Martin K. Rutter
- Division of Endocrinology, Diabetes & Gastroenterology, School of Medical Sciences, Faculty of Biology, Medicine and Health, University of Manchester
- Michael N. Weedon
- Genetics of Complex Traits, University of Exeter Medical School
- Richa Saxena
- Center for Genomic Medicine, Massachusetts General Hospital and Harvard Medical School
- DOI
- https://doi.org/10.1038/s41467-019-08917-4
- Journal volume & issue
-
Vol. 10,
no. 1
pp. 1 – 12
Abstract
Sleep is essential for homeostasis and insufficient or excessive sleep are associated with adverse outcomes. Here, the authors perform GWAS for self-reported habitual sleep duration in adults, supported by accelerometer-derived measures, and identify genetic correlation with psychiatric and metabolic traits
