Nature Communications (May 2017)

Glucose represses dendritic cell-induced T cell responses

  • Simon J. Lawless,
  • Nidhi Kedia-Mehta,
  • Jessica F. Walls,
  • Ryan McGarrigle,
  • Orla Convery,
  • Linda V. Sinclair,
  • Maria N. Navarro,
  • James Murray,
  • David K. Finlay

DOI
https://doi.org/10.1038/ncomms15620
Journal volume & issue
Vol. 8, no. 1
pp. 1 – 14

Abstract

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Glucose is an important nutrient that feeds into glycolytic control of T cell function and differentiation. Here the authors show that T cells are superior to dendritic cells (DC) at glucose uptake, and by depriving DCs of this nutrient in their microenvironment T cells activate DC proinflammatory functions, which in turn enhance T cell effector functions in DC-T cell cocultures.