npj Parkinson's Disease (Jun 2023)
Elucidating causative gene variants in hereditary Parkinson’s disease in the Global Parkinson’s Genetics Program (GP2)
- Lara M. Lange,
- Micol Avenali,
- Melina Ellis,
- Anastasia Illarionova,
- Ignacio J. Keller Sarmiento,
- Ai-Huey Tan,
- Harutyun Madoev,
- Caterina Galandra,
- Johanna Junker,
- Karisha Roopnarain,
- Justin Solle,
- Claire Wegel,
- Zih-Hua Fang,
- Peter Heutink,
- Kishore R. Kumar,
- Shen-Yang Lim,
- Enza Maria Valente,
- Mike Nalls,
- Cornelis Blauwendraat,
- Andrew Singleton,
- Niccolo Mencacci,
- Katja Lohmann,
- Christine Klein,
- the Global Parkinson’s Genetic Program (GP2)
Affiliations
- Lara M. Lange
- Institute of Neurogenetics, University of Lübeck
- Micol Avenali
- IRCCS Mondino Foundation
- Melina Ellis
- Northcott Neuroscience Laboratory, ANZAC Research Institute
- Anastasia Illarionova
- German Center for Neurodegenerative Diseases (DZNE)
- Ignacio J. Keller Sarmiento
- Department of Neurology, Northwestern University Feinberg School of Medicine
- Ai-Huey Tan
- Division of Neurology, Department of Medicine, and the Mah Pooi Soo and Tan Chin Nam Centre for Parkinson’s and Related Disorders, Faculty of Medicine, University of Malaya
- Harutyun Madoev
- Institute of Neurogenetics, University of Lübeck
- Caterina Galandra
- IRCCS Mondino Foundation
- Johanna Junker
- Institute of Neurogenetics, University of Lübeck
- Karisha Roopnarain
- Institute of Neurogenetics, University of Lübeck
- Justin Solle
- Department of Clinical Research, Michael J. Fox Foundation for Parkinson’s Research
- Claire Wegel
- Department of Medical and Molecular Genetics, Indiana University School of Medicine
- Zih-Hua Fang
- German Center for Neurodegenerative Diseases (DZNE)
- Peter Heutink
- German Center for Neurodegenerative Diseases (DZNE)
- Kishore R. Kumar
- Garvan Institute of Medical Research
- Shen-Yang Lim
- Division of Neurology, Department of Medicine, and the Mah Pooi Soo and Tan Chin Nam Centre for Parkinson’s and Related Disorders, Faculty of Medicine, University of Malaya
- Enza Maria Valente
- IRCCS Mondino Foundation
- Mike Nalls
- Data Tecnica International
- Cornelis Blauwendraat
- Center for Alzheimer’s and Related Dementias (CARD), National Institute on Aging and National Institute of Neurological Disorders and Stroke, National Institutes of Health
- Andrew Singleton
- Center for Alzheimer’s and Related Dementias (CARD), National Institute on Aging and National Institute of Neurological Disorders and Stroke, National Institutes of Health
- Niccolo Mencacci
- Department of Neurology, Northwestern University Feinberg School of Medicine
- Katja Lohmann
- Institute of Neurogenetics, University of Lübeck
- Christine Klein
- Institute of Neurogenetics, University of Lübeck
- the Global Parkinson’s Genetic Program (GP2)
- DOI
- https://doi.org/10.1038/s41531-023-00526-9
- Journal volume & issue
-
Vol. 9,
no. 1
pp. 1 – 5
Abstract
Abstract The Monogenic Network of the Global Parkinson’s Genetics Program (GP2) aims to create an efficient infrastructure to accelerate the identification of novel genetic causes of Parkinson’s disease (PD) and to improve our understanding of already identified genetic causes, such as reduced penetrance and variable clinical expressivity of known disease-causing variants. We aim to perform short- and long-read whole-genome sequencing for up to 10,000 patients with parkinsonism. Important features of this project are global involvement and focusing on historically underrepresented populations.
