Onsite GTP fuelling via DYNAMO1 drives division of mitochondria and peroxisomes

Yuuta Imoto; Yuichi Abe; Masanori Honsho; Kanji Okumoto; Mio Ohnuma; Haruko Kuroiwa; Tsuneyoshi Kuroiwa; Yukio Fujiki

doi:10.1038/s41467-018-07009-z

Nature Communications (Nov 2018)

Onsite GTP fuelling via DYNAMO1 drives division of mitochondria and peroxisomes

Yuuta Imoto,
Yuichi Abe,
Masanori Honsho,
Kanji Okumoto,
Mio Ohnuma,
Haruko Kuroiwa,
Tsuneyoshi Kuroiwa,
Yukio Fujiki

Affiliations

Yuuta Imoto: Division of Organelle Homeostasis, Medical Institute of Bioregulation, Kyushu University
Yuichi Abe: Division of Organelle Homeostasis, Medical Institute of Bioregulation, Kyushu University
Masanori Honsho: Division of Organelle Homeostasis, Medical Institute of Bioregulation, Kyushu University
Kanji Okumoto: Department of Biology, Faculty of Sciences, Kyushu University
Mio Ohnuma: Institute of Technology, Hiroshima College
Haruko Kuroiwa: Department of Chemical and Biological Science, Faculty of Science, Japan Women’s University
Tsuneyoshi Kuroiwa: Department of Chemical and Biological Science, Faculty of Science, Japan Women’s University
Yukio Fujiki: Division of Organelle Homeostasis, Medical Institute of Bioregulation, Kyushu University

DOI: https://doi.org/10.1038/s41467-018-07009-z
Journal volume & issue: Vol. 9, no. 1
pp. 1 – 12

Abstract

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Mitochondria and peroxisomes require a dynamin-like GTPase to remodel membranes during division. Here the authors identify DYNAMO1, a nucleoside diphosphate kinase-like protein that generates a local source of GTP to promote constriction of the division machinery and produce daughter organelles.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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