Progress and prospect of glucocorticoids therapy for severe cerebral venous thrombosis

Abstract

Severe cerebral venous thrombosis (CVT) is associated with serious clinical manifestations and poor prognosis, and current therapeutic strategies fail to substantially improve outcomes, necessitating exploration of novel therapeutic approaches. The latest studies have shown that inflammation is closely associated with the severity and poor prognosis of severe CVT, and anti-inflammatory therapy may be a very promising treatment. Despite ongoing debate regarding the role of glucocorticoids in severe CVT, recent studies indicate that short-term glucocorticoids pulse therapy may be a safe and effective intervention in acute/subacute severe CVT, which are likely due to suppression of the inflammatory response. This paper focuses on the latest research progress of glucocorticoids therapy for severe CVT, and points out that anti-inflammatory therapy targeting inflammation has great research potential in improving the prognosis of severe CVT. We wish to provide a novel, accessible, effective and safe anti-inflammatory therapy for patients with severe CVT.

Keywords

• venous thrombosis
• cerebral veins
• critical illness
• glucocorticoids
• inflammation