Neural Regeneration Research (Jan 2015)
Changes of resting cerebral activities in subacute ischemic stroke patients
- Ping Wu,
- Fang Zeng,
- Yong-xin Li,
- Bai-li Yu,
- Li-hua Qiu,
- Wei Qin,
- Ji Li,
- Yu-mei Zhou,
- Fan-rong Liang
Affiliations
- Ping Wu
- Fang Zeng
- Yong-xin Li
- Bai-li Yu
- Li-hua Qiu
- Wei Qin
- Ji Li
- Yu-mei Zhou
- Fan-rong Liang
- DOI
- https://doi.org/10.4103/1673-5374.156977
- Journal volume & issue
-
Vol. 10,
no. 5
pp. 760 – 765
Abstract
This study aimed to detect the difference in resting cerebral activities between ischemic stroke patients and healthy participants, define the abnormal site, and provide new evidence for pathological mechanisms, clinical diagnosis, prognosis prediction and efficacy evaluation of ischemic stroke. At present, the majority of functional magnetic resonance imaging studies focus on the motor dysfunction and the acute stage of ischemic stroke. This study recruited 15 right-handed ischemic stroke patients at subacute stage (15 days to 11.5 weeks) and 15 age-matched healthy participants. A resting-state functional magnetic resonance imaging scan was performed on each subject to detect cerebral activity. Regional homogeneity analysis was used to investigate the difference in cerebral activities between ischemic stroke patients and healthy participants. The results showed that the ischemic stroke patients had lower regional homogeneity in anterior cingulate and left cerebrum and higher regional homogeneity in cerebellum, left precuneus and left frontal lobe, compared with healthy participants. The experimental findings demonstrate that the areas in which regional homogeneity was different between ischemic stroke patients and healthy participants are in the cerebellum, left precuneus, left triangle inferior frontal gyrus, left inferior temporal gyrus and anterior cingulate. These locations, related to the motor, sensory and emotion areas, are likely potential targets for the neural regeneration of subacute ischemic stroke patients.
Keywords
- active zone stability
- Drosophila
- neuromuscular junction
- dephosphorylation
- Liprin-α
- Syd-1
- PP2A
- GSK-3ß
- living scaffolds
- neural tissue engineering
- cell transplant
- biomaterials
- regeneration
- neurotrauma
- neurodegeneration
- axon pathfinding
- cell migration
- injury
- plasticity
- neurodegenerative disease
- brain
- therapy
- neuron
- microglia
- neural progenitor
- tissue engineering
- neuroregeneration
- repair
- central nervous system
- biomaterial
- regenerative medicine
- nanotechnology
- spinal cord injury
- axonal regeneration
- exosome
- extracellular vesicle
- microRNA
- microvesicle
- nerve gap
- neurite outgrowth
- peripheral nerve injury
- Schwann cell
- stem cell
- hemodynamic phases
- cerebral subarachnoid hemorrhage
- metabolic crises
- nerve regeneration
- hypoxic-ischemic brain damage
- ginsenoside Rg1
- neural stem cells
- cell transplantation
- cell differentiation
- cognition
- nerve reconstruction
- neural regeneration
- nerve regeneration
- brain injury
- neuroimaging
- functional magnetic resonance imaging
- regional homogeneity
- apoplexy
- subacute
- ischemia
- participants
- healthy
- volunteers
- brain activity
- NSFC grants
- neural regeneration