Nature Communications (Feb 2021)

Single-cell RNA sequencing reveals functional heterogeneity of glioma-associated brain macrophages

  • Natalia Ochocka,
  • Pawel Segit,
  • Kacper Adam Walentynowicz,
  • Kamil Wojnicki,
  • Salwador Cyranowski,
  • Julian Swatler,
  • Jakub Mieczkowski,
  • Bozena Kaminska

DOI
https://doi.org/10.1038/s41467-021-21407-w
Journal volume & issue
Vol. 12, no. 1
pp. 1 – 14

Abstract

Read online

Microglia and peripheral myeloid cells are critically involved in the immunopathology of glioblastoma. Here the authors present single-cell sequencing data that assesses the phenotypic composition of CD11b + myeloid cells from a murine model of glioblastoma and suggest enhanced MHCII transcription which they additionally report from human cases of glioblastoma.