International Journal of Molecular Sciences (Mar 2023)
Ovarian Cancer and Glutamine Metabolism
- Zacharias Fasoulakis,
- Antonios Koutras,
- Thomas Ntounis,
- Ioannis Prokopakis,
- Paraskevas Perros,
- Athanasios Chionis,
- Ioakeim Sapantzoglou,
- Alexandros Katrachouras,
- Kyriakos Konis,
- Athina A. Samara,
- Asimina Valsamaki,
- Vasileios-Chrysovalantis Palios,
- Panagiotis Symeonidis,
- Konstantinos Nikolettos,
- Athanasios Pagkalos,
- Sotirios Sotiriou,
- Marianna Theodora,
- Panos Antsaklis,
- Georgios Daskalakis,
- Emmanuel N. Kontomanolis
Affiliations
- Zacharias Fasoulakis
- 1st Department of Obstetrics and Gynecology, General Hospital of Athens ‘ALEXANDRA’, National and Kapodistrian University of Athens, Lourou and Vasilissis Sofias Ave, 11528 Athens, Greece
- Antonios Koutras
- 1st Department of Obstetrics and Gynecology, General Hospital of Athens ‘ALEXANDRA’, National and Kapodistrian University of Athens, Lourou and Vasilissis Sofias Ave, 11528 Athens, Greece
- Thomas Ntounis
- 1st Department of Obstetrics and Gynecology, General Hospital of Athens ‘ALEXANDRA’, National and Kapodistrian University of Athens, Lourou and Vasilissis Sofias Ave, 11528 Athens, Greece
- Ioannis Prokopakis
- 1st Department of Obstetrics and Gynecology, General Hospital of Athens ‘ALEXANDRA’, National and Kapodistrian University of Athens, Lourou and Vasilissis Sofias Ave, 11528 Athens, Greece
- Paraskevas Perros
- 1st Department of Obstetrics and Gynecology, General Hospital of Athens ‘ALEXANDRA’, National and Kapodistrian University of Athens, Lourou and Vasilissis Sofias Ave, 11528 Athens, Greece
- Athanasios Chionis
- Department of Obstetrics and Gynecology, Laiko General Hospital of Athens, Agiou Thoma 17, 11527 Athens, Greece
- Ioakeim Sapantzoglou
- 1st Department of Obstetrics and Gynecology, General Hospital of Athens ‘ALEXANDRA’, National and Kapodistrian University of Athens, Lourou and Vasilissis Sofias Ave, 11528 Athens, Greece
- Alexandros Katrachouras
- Department of Obstetrics and Gynecology, University General Hospital of Ioannina, University of Ioannina, Stavrou Niarchou Str., 45500 Ioannina, Greece
- Kyriakos Konis
- Department of Obstetrics and Gynecology, General Hospital of Arta, Lofos Peranthis, 47100 Arta, Greece
- Athina A. Samara
- Department of Embryology, University Hospital of Larissa, Mezourlo, 41110 Larissa, Greece
- Asimina Valsamaki
- Department of Internal Medicine, General Hospital of Larisa, Tsakalof 1, 41221 Larisa, Greece
- Vasileios-Chrysovalantis Palios
- Department of Obstetrics and Gynecology, University General Hospital of Larissa, Mezourlo, 41110 Larissa, Greece
- Panagiotis Symeonidis
- Department of Obstetrics and Gynecology, University General Hospital of Alexandroupolis, 6th klm Alexandroupolis-Makris, Dragana Alexandroupolis, 68100 Alexandroupolis, Greece
- Konstantinos Nikolettos
- Department of Obstetrics and Gynecology, Democritus University of Thrace, 6th km Alexandroupolis-Makris, 68100 Alexandroupolis, Greece
- Athanasios Pagkalos
- Department of Obstetrics and Gynecology, General Hospital of Xanthi, Neapoli, 67100 Xanthi, Greece
- Sotirios Sotiriou
- Department of Embryology, Faculty of Medicine, School of Health Sciences, University of Thessaly, 41110 Larissa, Greece
- Marianna Theodora
- 1st Department of Obstetrics and Gynecology, General Hospital of Athens ‘ALEXANDRA’, National and Kapodistrian University of Athens, Lourou and Vasilissis Sofias Ave, 11528 Athens, Greece
- Panos Antsaklis
- 1st Department of Obstetrics and Gynecology, General Hospital of Athens ‘ALEXANDRA’, National and Kapodistrian University of Athens, Lourou and Vasilissis Sofias Ave, 11528 Athens, Greece
- Georgios Daskalakis
- 1st Department of Obstetrics and Gynecology, General Hospital of Athens ‘ALEXANDRA’, National and Kapodistrian University of Athens, Lourou and Vasilissis Sofias Ave, 11528 Athens, Greece
- Emmanuel N. Kontomanolis
- Department of Obstetrics and Gynecology, Democritus University of Thrace, 6th km Alexandroupolis-Makris, 68100 Alexandroupolis, Greece
- DOI
- https://doi.org/10.3390/ijms24055041
- Journal volume & issue
-
Vol. 24,
no. 5
p. 5041
Abstract
Cancer cells are known to have a distinct metabolic profile and to exhibit significant changes in a variety of metabolic mechanisms compared to normal cells, particularly glycolysis and glutaminolysis, in order to cover their increased energy requirements. There is mounting evidence that there is a link between glutamine metabolism and the proliferation of cancer cells, demonstrating that glutamine metabolism is a vital mechanism for all cellular processes, including the development of cancer. Detailed knowledge regarding its degree of engagement in numerous biological processes across distinct cancer types is still lacking, despite the fact that such knowledge is necessary for comprehending the differentiating characteristics of many forms of cancer. This review aims to examine data on glutamine metabolism and ovarian cancer and identify possible therapeutic targets for ovarian cancer treatment.
Keywords
