Epigenetically reprogrammed methylation landscape drives the DNA self-assembly and serves as a universal cancer biomarker

Abu Ali Ibn Sina; Laura G. Carrascosa; Ziyu Liang; Yadveer S. Grewal; Andri Wardiana; Muhammad J. A. Shiddiky; Robert A. Gardiner; Hemamali Samaratunga; Maher K. Gandhi; Rodney J. Scott; Darren Korbie; Matt Trau

doi:10.1038/s41467-018-07214-w

Nature Communications (Dec 2018)

Epigenetically reprogrammed methylation landscape drives the DNA self-assembly and serves as a universal cancer biomarker

Abu Ali Ibn Sina,
Laura G. Carrascosa,
Ziyu Liang,
Yadveer S. Grewal,
Andri Wardiana,
Muhammad J. A. Shiddiky,
Robert A. Gardiner,
Hemamali Samaratunga,
Maher K. Gandhi,
Rodney J. Scott,
Darren Korbie,
Matt Trau

Affiliations

Abu Ali Ibn Sina: Center for Personalised Nanomedicine, Australian Institute for Bioengineering and Nanotechnology (AIBN), Corner of College and Cooper Roads (Bldg 75), The University of Queensland
Laura G. Carrascosa: Center for Personalised Nanomedicine, Australian Institute for Bioengineering and Nanotechnology (AIBN), Corner of College and Cooper Roads (Bldg 75), The University of Queensland
Ziyu Liang: Center for Personalised Nanomedicine, Australian Institute for Bioengineering and Nanotechnology (AIBN), Corner of College and Cooper Roads (Bldg 75), The University of Queensland
Yadveer S. Grewal: Center for Personalised Nanomedicine, Australian Institute for Bioengineering and Nanotechnology (AIBN), Corner of College and Cooper Roads (Bldg 75), The University of Queensland
Andri Wardiana: Center for Personalised Nanomedicine, Australian Institute for Bioengineering and Nanotechnology (AIBN), Corner of College and Cooper Roads (Bldg 75), The University of Queensland
Muhammad J. A. Shiddiky: Center for Personalised Nanomedicine, Australian Institute for Bioengineering and Nanotechnology (AIBN), Corner of College and Cooper Roads (Bldg 75), The University of Queensland
Robert A. Gardiner: School of Medicine, The University of Queensland
Hemamali Samaratunga: School of Medicine, The University of Queensland
Maher K. Gandhi: Diamantina Institute, The University of Queensland
Rodney J. Scott: School of Biomedical Science and Pharmacy, The University of Newcastle
Darren Korbie: Center for Personalised Nanomedicine, Australian Institute for Bioengineering and Nanotechnology (AIBN), Corner of College and Cooper Roads (Bldg 75), The University of Queensland
Matt Trau: Center for Personalised Nanomedicine, Australian Institute for Bioengineering and Nanotechnology (AIBN), Corner of College and Cooper Roads (Bldg 75), The University of Queensland

DOI: https://doi.org/10.1038/s41467-018-07214-w
Journal volume & issue: Vol. 9, no. 1
pp. 1 – 13

Abstract

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DNA methylation is an epigenetic modification that control genetic programs. Here, the authors found that the methylation landscape influences the physicochemical properties of DNA and that it can serve as a universal cancer biomarker, and developed a one-step assay for the detection of cancer DNA.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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