Evolution of VIM-1-Producing Klebsiella pneumoniae Isolates from a Hospital Outbreak Reveals the Genetic Bases of the Loss of the Urease-Positive Identification Character
Nicolas Cabanel,
Isabelle Rosinski-Chupin,
Adriana Chiarelli,
Tatiana Botin,
Marta Tato,
Rafael Canton,
Philippe Glaser
Affiliations
Nicolas Cabanel
EERA Unit “Ecology and Evolution of Antibiotics Resistance,” Institut Pasteur-Assistance Publique/Hôpitaux de Paris-Université Paris-Saclay, Paris, France
Isabelle Rosinski-Chupin
EERA Unit “Ecology and Evolution of Antibiotics Resistance,” Institut Pasteur-Assistance Publique/Hôpitaux de Paris-Université Paris-Saclay, Paris, France
Adriana Chiarelli
EERA Unit “Ecology and Evolution of Antibiotics Resistance,” Institut Pasteur-Assistance Publique/Hôpitaux de Paris-Université Paris-Saclay, Paris, France
Tatiana Botin
EERA Unit “Ecology and Evolution of Antibiotics Resistance,” Institut Pasteur-Assistance Publique/Hôpitaux de Paris-Université Paris-Saclay, Paris, France
Marta Tato
Servicio de Microbiología, Hospital Universitario Ramón y Cajal and Instituto Ramón y Cajal de Investigación Sanitaria (IRYCIS), Madrid, Spain
Servicio de Microbiología, Hospital Universitario Ramón y Cajal and Instituto Ramón y Cajal de Investigación Sanitaria (IRYCIS), Madrid, Spain
EERA Unit “Ecology and Evolution of Antibiotics Resistance,” Institut Pasteur-Assistance Publique/Hôpitaux de Paris-Université Paris-Saclay, Paris, France
Evolution of multidrug-resistant bacterial pathogens occurs at multiple scales, in the patient, locally in the hospital, or more globally. Some mutations or gene acquisitions, for instance in response to antibiotic treatment, may be restricted to a single patient due to their high fitness cost.
