Lrp5 mutant and crispant zebrafish faithfully model human osteoporosis, establishing the zebrafish as a platform for CRISPR-based functional screening of osteoporosis candidate genes

• Jan Willem Bek,
• Chen Shochat,
• Adelbert De Clercq,
• Hanna De Saffel,
• Annekatrien Boel,
• Juriaan Metz,
• Frans Rodenburg,
• David Karasik,
• Andy Willaert,
• Paul Coucke

Affiliations

Jan Willem Bek

Gent University, Biomolecular Medicine, Gent, Belgium; Corresponding author.

Chen Shochat

Bar-Ilan University, The Musculoskeletal Genetics Laboratory, Safed, Israel

Adelbert De Clercq

Gent University, Biomolecular Medicine, Gent, Belgium

Hanna De Saffel

Gent University, Biomolecular Medicine, Gent, Belgium

Annekatrien Boel

Gent University, Biomolecular Medicine, Gent, Belgium; Gent University, Department for reproductive Medicine, Gent, Belgium

Juriaan Metz

Radboud University, Department of Animal Ecology and Physiology, Nijmegen, Netherlands

Frans Rodenburg

Leiden University, Institute of Biology, Leiden, Netherlands; Tokyo Institute of Technology, School of Life Science and Technology, Tokyo, Japan; Leiden University, Mathematical Institute, Leiden, Netherlands

David Karasik

Bar-Ilan University, The Musculoskeletal Genetics Laboratory, Safed, Israel; Harvard Medical School, Hinda and Arthur Marcus Institute for Aging Research, Boston, United States

Andy Willaert

Gent University, Biomolecular Medicine, Gent, Belgium

Paul Coucke

Gent University, Biomolecular Medicine, Gent, Belgium