Highly selective nickel-catalyzed gem-difluoropropargylation of unactivated alkylzinc reagents

Abstract

Difluoroalkylated compounds find wide application in medicinal chemistry. Here, the authors describe the mild nickel-catalyzed difluoroalkylation of aliphatic alkylzinc reagents with gem-difluoropropargylbromides and show its utility in a number of post-synthetic transformations.