Nature Communications (Jun 2021)
Bladder cancer therapy using a conformationally fluid tumoricidal peptide complex
- Antonín Brisuda,
- James C. S. Ho,
- Pancham S. Kandiyal,
- Justin T-Y. Ng,
- Ines Ambite,
- Daniel S. C. Butler,
- Jaromir Háček,
- Murphy Lam Yim Wan,
- Thi Hien Tran,
- Aftab Nadeem,
- Tuan Hiep Tran,
- Anna Hastings,
- Petter Storm,
- Daniel L. Fortunati,
- Parisa Esmaeili,
- Hana Novotna,
- Jakub Horňák,
- Y. G. Mu,
- K. H. Mok,
- Marek Babjuk,
- Catharina Svanborg
Affiliations
- Antonín Brisuda
- Department of Urology, Motol University Hospital, 2nd Faculty of Medicine, Charles University Praha
- James C. S. Ho
- Division of Microbiology, Immunology and Glycobiology, Department of Laboratory Medicine, Faculty of Medicine, Lund University
- Pancham S. Kandiyal
- Trinity Biomedical Sciences Institute (TBSI), School of Biochemistry & Immunology, Trinity College Dublin, The University of Dublin
- Justin T-Y. Ng
- School of Biological Sciences, Nanyang Technological University
- Ines Ambite
- Division of Microbiology, Immunology and Glycobiology, Department of Laboratory Medicine, Faculty of Medicine, Lund University
- Daniel S. C. Butler
- Division of Microbiology, Immunology and Glycobiology, Department of Laboratory Medicine, Faculty of Medicine, Lund University
- Jaromir Háček
- Department of Pathology and Molecular Medicine, Motol University Hospital, 2nd Faculty of Medicine, Charles University Praha
- Murphy Lam Yim Wan
- Division of Microbiology, Immunology and Glycobiology, Department of Laboratory Medicine, Faculty of Medicine, Lund University
- Thi Hien Tran
- Division of Microbiology, Immunology and Glycobiology, Department of Laboratory Medicine, Faculty of Medicine, Lund University
- Aftab Nadeem
- Division of Microbiology, Immunology and Glycobiology, Department of Laboratory Medicine, Faculty of Medicine, Lund University
- Tuan Hiep Tran
- Division of Microbiology, Immunology and Glycobiology, Department of Laboratory Medicine, Faculty of Medicine, Lund University
- Anna Hastings
- Trinity Biomedical Sciences Institute (TBSI), School of Biochemistry & Immunology, Trinity College Dublin, The University of Dublin
- Petter Storm
- Division of Microbiology, Immunology and Glycobiology, Department of Laboratory Medicine, Faculty of Medicine, Lund University
- Daniel L. Fortunati
- Trinity Biomedical Sciences Institute (TBSI), School of Biochemistry & Immunology, Trinity College Dublin, The University of Dublin
- Parisa Esmaeili
- Division of Microbiology, Immunology and Glycobiology, Department of Laboratory Medicine, Faculty of Medicine, Lund University
- Hana Novotna
- Department of Urology, Motol University Hospital, 2nd Faculty of Medicine, Charles University Praha
- Jakub Horňák
- Department of Urology, Motol University Hospital, 2nd Faculty of Medicine, Charles University Praha
- Y. G. Mu
- School of Biological Sciences, Nanyang Technological University
- K. H. Mok
- Trinity Biomedical Sciences Institute (TBSI), School of Biochemistry & Immunology, Trinity College Dublin, The University of Dublin
- Marek Babjuk
- Department of Urology, Motol University Hospital, 2nd Faculty of Medicine, Charles University Praha
- Catharina Svanborg
- Division of Microbiology, Immunology and Glycobiology, Department of Laboratory Medicine, Faculty of Medicine, Lund University
- DOI
- https://doi.org/10.1038/s41467-021-23748-y
- Journal volume & issue
-
Vol. 12,
no. 1
pp. 1 – 16
Abstract
Partially unfolded alpha-lactalbumin forms an oleic acid complex with antitumorigenic properties. Here, the authors define a structurally flexible, peptide-based oleate complex and report a phase I/II clinical trial where this complex is used to treat patients with bladder cancer.
