BMC Medical Research Methodology (Jun 2020)
Bayesian alternatives to null hypothesis significance testing in biomedical research: a non-technical introduction to Bayesian inference with JASP
Abstract
Abstract Background Although null hypothesis significance testing (NHST) is the agreed gold standard in medical decision making and the most widespread inferential framework used in medical research, it has several drawbacks. Bayesian methods can complement or even replace frequentist NHST, but these methods have been underutilised mainly due to a lack of easy-to-use software. JASP is an open-source software for common operating systems, which has recently been developed to make Bayesian inference more accessible to researchers, including the most common tests, an intuitive graphical user interface and publication-ready output plots. This article provides a non-technical introduction to Bayesian hypothesis testing in JASP by comparing traditional tests and statistical methods with their Bayesian counterparts. Results The comparison shows the strengths and limitations of JASP for frequentist NHST and Bayesian inference. Specifically, Bayesian hypothesis testing via Bayes factors can complement and even replace NHST in most situations in JASP. While p-values can only reject the null hypothesis, the Bayes factor can state evidence for both the null and the alternative hypothesis, making confirmation of hypotheses possible. Also, effect sizes can be precisely estimated in the Bayesian paradigm via JASP. Conclusions Bayesian inference has not been widely used by now due to the dearth of accessible software. Medical decision making can be complemented by Bayesian hypothesis testing in JASP, providing richer information than single p-values and thus strengthening the credibility of an analysis. Through an easy point-and-click interface researchers used to other graphical statistical packages like SPSS can seemlessly transition to JASP and benefit from the listed advantages with only few limitations.
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