Daily oral supplementation of Hochu-Ekki-To prevents osteoclastic activation and bone loss in ovariectomized mice

Shinsuke Ochiai; Kazuya Tokumura; Gyujin Park; Kakeru Ozaki; Tetsuhiro Horie; Takanori Yamada; Sayuki Iwahashi; Kaname Ohta; Hiroki Fusawa; Yasuka Okayama; Katsuyuki Kaneda; Takashi Iezaki; Eiichi Hinoi

Journal of Pharmacological Sciences (Jan 2021)

Daily oral supplementation of Hochu-Ekki-To prevents osteoclastic activation and bone loss in ovariectomized mice

Shinsuke Ochiai,
Kazuya Tokumura,
Gyujin Park,
Kakeru Ozaki,
Tetsuhiro Horie,
Takanori Yamada,
Sayuki Iwahashi,
Kaname Ohta,
Hiroki Fusawa,
Yasuka Okayama,
Katsuyuki Kaneda,
Takashi Iezaki,
Eiichi Hinoi

Affiliations

Shinsuke Ochiai: Laboratory of Pharmacology, Department of Bioactive Molecules, Gifu Pharmaceutical University, Gifu, Japan
Kazuya Tokumura: Laboratory of Pharmacology, Department of Bioactive Molecules, Gifu Pharmaceutical University, Gifu, Japan
Gyujin Park: Laboratory of Pharmacology, Department of Bioactive Molecules, Gifu Pharmaceutical University, Gifu, Japan
Kakeru Ozaki: Laboratory of Molecular Pharmacology, Division of Pharmaceutical Sciences, Kanazawa University Graduate School, Kanazawa, Ishikawa, Japan
Tetsuhiro Horie: Laboratory of Pharmacology, Department of Bioactive Molecules, Gifu Pharmaceutical University, Gifu, Japan
Takanori Yamada: Laboratory of Pharmacology, Department of Bioactive Molecules, Gifu Pharmaceutical University, Gifu, Japan
Sayuki Iwahashi: Laboratory of Pharmacology, Department of Bioactive Molecules, Gifu Pharmaceutical University, Gifu, Japan
Kaname Ohta: Laboratory of Pharmacology, Department of Bioactive Molecules, Gifu Pharmaceutical University, Gifu, Japan
Hiroki Fusawa: Laboratory of Pharmacology, Department of Bioactive Molecules, Gifu Pharmaceutical University, Gifu, Japan
Yasuka Okayama: Laboratory of Pharmacology, Department of Bioactive Molecules, Gifu Pharmaceutical University, Gifu, Japan
Katsuyuki Kaneda: Laboratory of Molecular Pharmacology, Division of Pharmaceutical Sciences, Kanazawa University Graduate School, Kanazawa, Ishikawa, Japan
Takashi Iezaki: Laboratory of Pharmacology, Department of Bioactive Molecules, Gifu Pharmaceutical University, Gifu, Japan
Eiichi Hinoi: Laboratory of Pharmacology, Department of Bioactive Molecules, Gifu Pharmaceutical University, Gifu, Japan; United Graduate School of Drug Discovery and Medical Information Sciences, Gifu University, Gifu, Japan; Corresponding author. 1-25-4, Daigaku-nishi, Gifu, 501-1196, Japan. Fax: +81 0 58 230 8123.

Journal volume & issue: Vol. 145, no. 1
pp. 1 – 5

Abstract

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Bone remodeling is sophisticatedly regulated by two different cell types: bone-resorbing osteoclasts and bone-forming osteoblasts. Hochu-Ekki-To, a Japanese traditional herbal medicine, is commonly used for the treatment of chronic diseases or frailty after an illness; however, its effects on metabolic bone diseases such as osteoporosis are not well known. We herein report that daily oral Hochu-Ekki-To administration significantly inhibits osteoclast activation as well as the reduction in bone volume in ovariectomized mice. Our results suggest that supplementation with Hochu-Ekki-To might be beneficial for the prophylaxis and treatment of metabolic bone diseases associated with abnormal osteoclast activation.

Published in Journal of Pharmacological Sciences

ISSN: 1347-8613 (Print)
Publisher: Elsevier
Country of publisher: Japan
LCC subjects: Medicine: Therapeutics. Pharmacology
Website: http://www.journals.elsevier.com/journal-of-pharmacological-sciences

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