Potential magnetic drug targeting with magnetite nanoparticles in cancer treatment by enhancer-modifier natural herb and loaded drug

Maria Waqar; Syeda Ammara Batool; Zahida Yaqoob; Jawad Manzur; Mohamed Abbas; Thafasalijyas Vayalpurayil; Muhammad Atiq Ur Rehman

Heliyon (Jun 2024)

Potential magnetic drug targeting with magnetite nanoparticles in cancer treatment by enhancer-modifier natural herb and loaded drug

Maria Waqar,
Syeda Ammara Batool,
Zahida Yaqoob,
Jawad Manzur,
Mohamed Abbas,
Thafasalijyas Vayalpurayil,
Muhammad Atiq Ur Rehman

Affiliations

Maria Waqar: Department of Materials Science & Engineering, Institute of Space Technology Islamabad, 1, Islamabad Highway, Islamabad, 44000, Pakistan
Syeda Ammara Batool: Department of Materials Science & Engineering, Institute of Space Technology Islamabad, 1, Islamabad Highway, Islamabad, 44000, Pakistan
Zahida Yaqoob: Department of Materials Science & Engineering, Institute of Space Technology Islamabad, 1, Islamabad Highway, Islamabad, 44000, Pakistan; Centre of Excellence in Biomaterials and Tissue Engineering, Department of Materials Science and Engineering Government College University Lahore, 54000, Pakistan
Jawad Manzur: Centre of Excellence in Biomaterials and Tissue Engineering, Department of Materials Science and Engineering Government College University Lahore, 54000, Pakistan
Mohamed Abbas: Central Labs, King Khalid University, AlQura'a, Abha, P.O. Box 960, Saudi Arabia; Electrical Engineering Department, College of Engineering, King Khalid University, Abha 61421, Saudi Arabia
Thafasalijyas Vayalpurayil: Central Labs, King Khalid University, AlQura'a, Abha, P.O. Box 960, Saudi Arabia; Electrical Engineering Department, College of Engineering, King Khalid University, Abha 61421, Saudi Arabia
Muhammad Atiq Ur Rehman: Department of Materials Science & Engineering, Institute of Space Technology Islamabad, 1, Islamabad Highway, Islamabad, 44000, Pakistan; Corresponding author.

Journal volume & issue: Vol. 10, no. 11
p. e32484

Abstract

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In the present study, we prepared magnetite nanoparticles (MNPs) loaded with natural Moringa oleifera (M. olf) herb and Epilim (Ep) drug to evaluate the anti-cancerous activity against brain cancer cells. All the samples were prepared via co-precipitation approach modified with different concentrations of M. olf and Ep drug at room temperature. The MNPs loaded with drug and natural herb were studied in terms of crystal structure, morphology, colloidal stability, size distribution, and magnetic properties. Field emission scanning electron microscopy (FESEM) images exhibited the morphologies of samples with spherical shape as well as the particles size of 9 nm for MNPs and up to 23 nm for its composites. The results of vibrating sample magnetometer (VSM) indicated the magnetization saturation (Ms) of 42.510 emu/g for MNPs. This value reduced to 16–35 emu/g upon loading MNPs with different concentrations of M. olf and Ep. Fourier transform infrared spectroscopy (FTIR) indicated the chemical interaction between the Ep, M.olf and MNPs. Brunauer-Emmett-Teller (BET) analysis confirmed the largest surface area for MNPs (422.61 m2/g) which gradually reduced on addition of M. olf and Ep indicating the successful loading. The zeta potential measurements indicated that the MNPs and MNPs loaded with M. olf and Ep are negatively charged and can be dispersed in the suspension. Furthermore, U87 human glioblastoma cell line was used for the in vitro cellular studies to determine the efficacy of synthesized MNPs against cancer cells. The results confirmed the anti-proliferative activity of the MNPs loaded with M. olf and Ep.

Published in Heliyon

ISSN: 2405-8440 (Online)
Publisher: Elsevier
Country of publisher: United Kingdom
LCC subjects: Science: Science (General); Social Sciences: Social sciences (General)
Website: https://www.cell.com/heliyon/home

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